11-Dehydro-thromboxane B2
Based on 1 Customer Validation
11-Dehydro-thromboxane B2 is a stable terminal metabolite of thromboxane A2 and an agonist of the CRTH2 receptor. 11-Dehydro-TXB2 activates human eosinophils, basophils, and CRTH2-transfected BaF/3 cells through a pertussis toxin-insensitive G protein-PLC pathway, inducing intracellular calcium mobilization, morphological changes, and chemotaxis, but does not affect platelet aggregation. 11-Dehydro-thromboxane B2 is involved in thrombosis and promotes eosinophil recruitment to the lungs in allergic inflammation, and its urinary levels are used to assess the inhibitory effect of Aspirin (HY-14654) on thromboxane production. 11-Dehydro-TXB2 serves as a biomarker for research related to asthma, atopic rhinitis, nephropathy, and coronary artery disease.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 67910-12-7
- Formula: C20H32O6
- Molecular Weight:368.46
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
[2]|
Human Endogenous Metabolite |
In Vitro
11-Dehydro-thromboxane B2 (10 μM; 4-6 min) induces calcium influx in human eosinophils, and this calcium influx is primarily derived from intracellular stores, while also producing cross-desensitization of PGD2-mediated calcium responses, confirming that both share the same receptor[1].
11-Dehydro-thromboxane B2 (1-5 h) induces chemotaxis in human eosinophils and hCRTH2-transfected BaF/3 cells[1].
11-Dehydro-thromboxane B2 induces morphological changes in human eosinophils that are not inhibited by pertussis toxin and involve phospholipase C activation, consistent with the signaling pathway mediated by PGD2 through CRTH2[1].
11-Dehydro-thromboxane B2 (4-5 min)-induced morphological changes in human eosinophils are inhibited by the CRTH2/TP antagonist Ramatroban (HY-B0745), but not by the selective TP antagonist SQ29,548 (HY-108972), confirming that this process is mediated by CRTH2[1].
11-Dehydro-thromboxane B2 exhibits no CRTH2 antagonistic activity at its threshold activation concentration, confirming that it is a full CRTH2 agonist[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 67910-12-7
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Appearance Liquid
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Molecular Weight 368.46
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Formula C20H32O6
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Color Colorless to light yellow
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SMILES
O=C(O)CCC/C=C\C[C@@H]([C@@H](O)C1)[C@@H](/C=C/[C@@H](O)CCCCC)OC1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
11-Dehydro-thromboxane B2 Related Classifications
HY-113420 Related Classifications
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