CDC-like kinase 3 (CLK3)
CDC-like kinase 3 (CLK3) belongs to the CLK/LAMMER family of dual-specificity protein kinases, named after the conserved LAMMER sequence motif within the catalytic domain. Unlike receptor or cytoplasmic signaling kinases, CLK3 acts predominantly in the nucleus, where it phosphorylates serine/arginine-rich (SR) splicing factors on serine, threonine, and tyrosine residues. This phosphorylation modulates the localization and activity of SR proteins, thereby shaping alternative pre-mRNA splicing patterns and expanding proteome diversity. Altered CLK3 expression has been reported in several cancers, and its control of splicing factor dynamics has made it a subject of interest for therapies directed against aberrant splicing programs.
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CDC-like kinase 3 (CLK3) Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
