Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
(72)
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Neuropeptide Y Receptor Antagonists
(62)
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Neuropeptide Y Receptor Activators
(2)
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Neuropeptide Y Receptor Modulators
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Neuropeptide Y Receptor Control
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Neuropeptide Y Receptor Related Products (182)
Related Products (182)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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BIBO3304
0 ImagesBIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
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Neuropeptide Y (human,rat,mouse)
0 ImagesSynonyms: Neuropeptide Y (29-64), amideNeuropeptide Y (human,rat,mouse) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
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BIIE-0246
0 ImagesSynonyms: AR-H 053591BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
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BIBP3226 TFA
0 ImagesBIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.
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Peptide YY (PYY) (3-36), Human
0 ImagesPeptide YY (PYY) (3-36), Human is an endogenous appetite-suppressing peptide that acts as a selective agonist of neuropeptide Y (NPY) Y2 receptor. Peptide YY (PYY) (3-36), Human inhibits intestinal fluid secretion, colonic propulsion, and reduces fecal output in mouse models. Peptide YY (PYY) (3-36), Human inhibits dmPGE2-, 5HT (HY-B1473A)-, and Castor oil (HY-107799)-induced diarrhea in mice. Peptide YY (PYY) (3-36), Human improves metabolic parameters and mitochondrial function in obese rat MASLD models. Peptide YY (PYY) (3-36), Human can be used for research on intestinal diseases such as diarrhea and metabolic dysfunction-associated steatotic liver disease.
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SR 142948
0 ImagesSR 142948 is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC50s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders.
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NTNCB hydrochloride
0 ImagesNTNCB hydrochloride is a selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a Ki value of 8 nM for human Y5. NTNCB hydrochloride inhibits the proliferation and metastasis of cancer cells, suppresses xenograft tumor growth in vivo, and induces apoptosis in cancer cells. NTNCB hydrochloride inhibits microglial viability and reverses AURKA, CDC20, CDK1, and EZH2 as well as several cancer-overexpressed genes in cancer cells. NTNCB hydrochloride can be used in research on castration-resistant prostate cancer, non-small cell lung cancer, and obesity.
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Peptide YY (PYY), human
0 ImagesPeptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
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Neuropeptide Y (human,rat,mouse) TFA
0 ImagesCat. No.: HY-P0198APurity: 99.28%Neuropeptide Y (human) TFA is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
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JNJ-31020028
0 ImagesJNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
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M871
0 ImagesSynonyms: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amideM871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain).
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MK-0557
0 ImagesMK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
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HT-2157
0 ImagesSynonyms: SNAP 37889HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
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[Leu31,Pro34]-Neuropeptide Y (porcine)
![[Leu31,Pro34]-Neuropeptide Y (porcine)](https://file.medchemexpress.com/product_pic/hy-p0208.gif "Click to View [Leu31,Pro34]-Neuropeptide Y (porcine) Product Detail")
0 Images[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.
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Neuropeptide Y(29-64)
0 ImagesNeuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.
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RF9
0 ImagesRF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
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[Leu31,Pro34]-Neuropeptide Y (human,rat,mouse) TFA
![[Leu31,Pro34]-Neuropeptide Y (human,rat,mouse) TFA](https://file.medchemexpress.com/product_pic/hy-p1323a.gif "Click to View [Leu31,Pro34]-Neuropeptide Y (human,rat,mouse) TFA Product Detail")
0 ImagesCat. No.: HY-P1323APurity: 98.00%[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.
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CGP71683 hydrochloride
0 ImagesSynonyms: CGP71683ACGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
