Furin
Furin
Furin belongs to the proprotein convertase (PC) family. Furin is able to recognize specific amino acid sequences and cleave the protein precursors at these sequences, thereby converting inactive precursor proteins into mature proteins with functional activity. Furin is involved in the processing and maturation of intracellular proteins, such as coagulation factor Ⅷ and angiotensinogen. By cleaving cell surface receptors and signaling molecules, Furin participates in cell signaling transduction and regulates various vital activities of cells, such as cell proliferation, differentiation, and apoptosis. In addition, during viral infections, Furin can cleave the glycoproteins on the surface of the virus, promoting the fusion of the virus with the host cell membrane and facilitating the entry of the virus into the host cell. Furin plays an important role in a variety of diseases, including cardiovascular diseases, tumors, neurodegenerative diseases, and infectious diseases[1][2].
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Furin Related Products (12)
Related Products (12)
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Antibodies (2)
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Boc-Arg-Val-Arg-Arg-AMC hydrochloride
0 ImagesSynonyms: Boc-RVRR-AMCBoc-Arg-Val-Arg-Arg-AMC hydrochloride (Boc-RVRR-AMC) is a synthetic fluorogenic substrate that is efficiently cleaved by furin.
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DEC-RVRK-CMK TFA
0 ImagesCat. No.: HY-P5062APurity: 99.04%Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFADEC-RVRK-CMK TFA (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK TFA is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK TFA inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK TFA holds promise for antiviral infection-related research.
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SSM3 tetraTFA hydrate
0 ImagesCat. No.: HY-110147BPurity: 99.9%SSM-3 tetraTFA hydrate is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA hydrate uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA hydrate can be used in the research of anthrax and avian influenza.
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DEC-RVRK-CMK
0 ImagesCat. No.: HY-P5062CAS No.: 534615-50-4Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketoneDEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK holds promise for antiviral infection-related research.
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PAI-1-IN-1
0 ImagesPAI-1-IN-1 is an orally active and specific PAI-1 inhibitor with an IC50 of <6.95 μM. PAI-1-IN-1 blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. PAI-1-IN-1 restores macrophage efferocytosis and promotes macrophage polarization. PAI-1-IN-1 alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. PAI-1-IN-1 promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. PAI-1-IN-1 can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia.
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PAI-1
0 ImagesPAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus.
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SSM3 tetraTFA
0 ImagesCat. No.: HY-110147ACAS No.: 2320930-10-5SSM-3 tetraTFA is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 tetraTFA uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 tetraTFA can be used in the research of anthrax and avian influenza.
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Furin-IN-3
0 ImagesCat. No.: HY-180145CAS No.: 3080672-14-3
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Furin Substrate
0 ImagesCat. No.: HY-P3797CAS No.: 174838-79-0
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SSM-3
0 ImagesCat. No.: HY-110147CAS No.: 922732-52-3SSM-3 is a potent furin inhibitor with an EC50 of 54 nM. SSM-3 uses its positively charged guanidyl group to form strong electrostatic interactions with the negatively charged residues in the catalytic center of furin, thereby competitively occupying and blocking the active site. SSM-3 can be used in the research of anthrax and avian influenza.
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