Fc-gamma Receptor I/CD64
Fc-gamma receptor I, designated CD64, is the sole high-affinity IgG Fc receptor in humans, expressed constitutively on monocytes and macrophages and inducible on neutrophils by IFN-gamma and G-CSF. Unlike low-affinity Fc gamma receptors that bind only immune complexes, CD64 binds monomeric IgG1 and IgG3 with nanomolar affinity through three extracellular immunoglobulin-like domains, making the receptor occupied even at resting IgG concentrations. Crosslinking triggers phagocytosis, antibody-dependent cellular cytotoxicity and release of inflammatory cytokines via ITAM-bearing gamma chain adaptors. Upregulation of CD64 on neutrophils is an early biomarker of bacterial infection and neonatal sepsis.
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Fc-gamma Receptor I/CD64 Recombinant Proteins (12)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
