Pyruvate Carboxylase (PC)
Pyruvate Carboxylase
Pyruvate carboxylase (PC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical step in the tricarboxylic acid (TCA) cycle. It typically functions as a tetramer composed of four identical subunits, each with a molecular weight of approximately 120-130 kDa. PC is essential for various anabolic processes, including gluconeogenesis, lipogenesis, insulin secretion, and the synthesis of glutamate neurotransmitters[1].
In cancer cells, PC plays a pivotal role in metabolic reprogramming and adaptation, contributing to lipid metabolism and protection against oxidative stress. Clinically, pyruvate carboxylase deficiency is a rare metabolic disorder characterized by lactic acidemia, encephalopathy, and prominent neurological symptoms during the neonatal and infantile periods. This highlights PC's critical role in energy metabolism and brain function[2].
In cancer cells, PC plays a pivotal role in metabolic reprogramming and adaptation, contributing to lipid metabolism and protection against oxidative stress. Clinically, pyruvate carboxylase deficiency is a rare metabolic disorder characterized by lactic acidemia, encephalopathy, and prominent neurological symptoms during the neonatal and infantile periods. This highlights PC's critical role in energy metabolism and brain function[2].
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Pyruvate Carboxylase (PC) Related Products (10)
Related Products (10)
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ZY-444
0 ImagesZY-444 is an anti-cancer agent, targeting pyruvate carboxylase (PC). ZY-444 suppresses the Wnt/β-catenin/Snail signaling pathway by blocking nuclear translocation of β-catenin. ZY-444 selectively inhibits proliferation, migration, and invasion and induces apoptosis in cancer cells. ZY-444 exhibits potent anti-tumor in cancer mouse models. ZY-444 can be used for the study of breast cancer, lung cancer (NSCLC), prostate cancer and iodine-refractory thyroid cancer.
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DEC-RVRK-CMK TFA
0 ImagesCat. No.: HY-P5062APurity: 99.04%Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFADEC-RVRK-CMK TFA (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK TFA is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK TFA inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK TFA holds promise for antiviral infection-related research.
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Pyruvate Carboxylase-IN-5
0 ImagesPyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose.
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Anemoside A3-methyl 6-aminohexanoate
0 ImagesAnemoside A3-methyl 6-aminohexanoate is an orally effective pyruvate carboxylase (PC) inhibitor with a Kd value of 10.1 μM against human PC. Anemoside A3-methyl 6-aminohexanoate exerts its function through the PC/NF-κB/NLRP3 inflammasome axis. Anemoside A3-methyl 6-aminohexanoate significantly alleviates symptoms of DSS (HY-116282C)-induced colitis in mice. Anemoside A3-methyl 6-aminohexanoate can be used in colitis-related research.
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DEC-RVRK-CMK
0 ImagesCat. No.: HY-P5062CAS No.: 534615-50-4Synonyms: Decanoyl-Arg-Val-Arg-Lys-chloromethylketoneDEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptidyl CMK inhibitor that targets the calcium-dependent subtilisin-like proprotein convertase family. DEC-RVRK-CMK is a furin-targeting proprotein convertase inhibitor that blocks the cleavage and maturation of inhibin α-subunit and βB-subunit precursors. DEC-RVRK-CMK inhibits PC4-mediated proteolysis with an IC50 of 12.2 nM in rats. DEC-RVRK-CMK holds promise for antiviral infection-related research.
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CIB-Q22
0 ImagesCIB-Q22 is a potent pyruvate carboxylase (PC) inhibitor with an IC50 of 1.74 nM. CIB-Q22 suppresses hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion. CIB-Q22 induces apoptosis and ferroptosis, promotes mitochondrial oxidative stress and dysfunction, inhibits glycolysis and anaplerotic flux, and reverses epithelial-mesenchymal transition (EMT). CIB-Q22 can be used for the study of hepatocellular carcinoma.
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Pyruvate Carboxylase-IN-4
0 ImagesCat. No.: HY-161680CAS No.: 2369048-06-4Pyruvate Carboxylase-IN-4 (Compd 8V) is a potent and competitive Pyruvate Carboxylase inhibitor with an IC50 of 4.3 μM.
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Dracoflavan B2
0 ImagesCat. No.: HY-N21583CAS No.: 194794-47-3Dracoflavan B2 is an allosteric activator of pyruvate carboxylase (PC) that enhances Oxaloacetic acid (HY-W010382) production by inducing conformational changes in the BCCP domain, restores mitochondrial function, and improves metabolism, while also exhibiting anti-inflammatory activity. Dracoflavan B2 can be used for research on myocardial infarction.
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Formycin triphosphate
0 ImagesCat. No.: HY-161681CAS No.: 16409-13-5Formycin triphosphate is a fluorescent ATP analog. Formycin triphosphate is a competitive inhibitor of chicken liver pyruvate carboxylase with respect to ATP. Formycin triphosphate can be used in research on human colon cancer.
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Insecticidal agent 26
0 ImagesCat. No.: HY-178040Insecticidal agent 26 (Compound A11), a spiro insecticidal agent, is a dual-functional inhibitor of pest Acetyl-CoA carboxylase (ACC) and Pyruvate carboxylase (PC). Insecticidal agent 26 has potent insecticidal activity against Sogatella furcifera with a LC50 of 11.0 μg/mL, with significant biosafety to bees. Insecticidal agent 26 can be used for management of white-backed planthoppers (WBPs).
