Cat. No.: HY-L267

Protein Synthesis Regulatory Compound Library

97 Cited Publications

Customer Review

Based on 97 publication(s) in Google Scholar

Protein synthesis is a fundamental process that converts genetic information into functional proteins and is essential for maintaining cellular growth, proliferation, differentiation, and metabolic homeostasis. Protein synthesis is precisely regulated by a complex network of signaling pathways, including mTOR, PI3K/Akt, MAPK/ERK, and eIF (eukaryotic translation initiation factor)-mediated signaling. These pathways finely control cellular protein synthesis by regulating translation initiation, ribosomal activity, and the expression and phosphorylation status of key translation factors. Dysregulation of protein synthesis is closely associated with the development and progression of various diseases, including cancer, metabolic disorders, neurodegenerative diseases, and immune-related disorders. Therefore, key proteins, kinases, and translation regulators within these pathways are of significant value for research and drug development.

MCE offers 1,226 small-molecule compounds targeting key components of protein synthesis signaling pathways, covering multiple targets involved in protein synthesis and translational regulation, as well as diverse modes of target modulation and functions. By selectively modulating the activity or function of different pathway components, these compounds can be used to investigate protein synthesis and translational regulatory networks, elucidate the roles of specific targets in cellular physiology and disease processes, and support disease mechanism studies, potential drug target validation, candidate drug evaluation, and the exploration of therapeutic strategies.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

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Description & Advantages
Product Details
- Formulation
- Layout
- Container
- Storage
- Shipping
Publications (97)
Documentation
Composition

Description & Advantages

• A unique collection of 1,226 small-molecule compounds targeting protein synthesis signaling pathways, which can be used for the study of translational regulation and related diseases.

• Structurally diverse, bioactive, and cell permeable.

• More detailed compound information with structure, IC50, and other chemical & biological data.

• High purity and quality validated by NMR and LC/MS.

• All compounds are in stock and continuously updated.

Product Details

Formulation

A collection of 1,226 compounds regulating protein synthesis, supplied as pre-dissolved solutions or solids.

Solution: 1,182 compounds supplied in 10 mM solution, 40 compounds supplied in 2 mM solution, 4 compounds supplied in 3 mg/mL solution.

Layout

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage

-80°C

Shipping

Blue ice or dry ice