Checkpoint Kinase 1 (Chk1)
Checkpoint kinase 1 (Chk1, encoded by CHEK1) is the principal effector kinase downstream of ATR in the DNA damage and replication stress checkpoints. Although classified here within the CAMKL group, Chk1 responds to genome-instability signals rather than calcium. ATR phosphorylates its C-terminal regulatory region, activating Chk1 to phosphorylate Cdc25A, targeting it for degradation, and Cdc25C, which is sequestered in the cytoplasm, keeping CDK1/2 inactive and arresting cell-cycle progression. Chk1 also stabilizes stalled replication forks and modulates p53-dependent fate decisions, and it is essential for viability. Recombinant Chk1 is widely used in checkpoint kinase assays and in screening Chk1 inhibitors developed as chemopotentiators.
-
Checkpoint Kinase 1 (Chk1) Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
