Hormone-Sensitive Lipase (HSL)
Hormone-Sensitive Lipase (HSL); cholesteryl ester hydrolase; triacylglycerol lipase
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water-soluble substrates. HSL is highly expressed in adipose tissue and steroidogenic tissues, with lower amounts found in cardiac and skeletal muscle, macrophages, and pancreatic islets. HSL contains two main domains: the N-terminal domain and the C-terminal domain. The C-terminal portion forms an α/β hydrolase structure and contains the catalytic triad: Ser-423, Asp-703, and His-733. In normal physiology, HSL affects adipocyte lipolysis, steroidogenesis, spermatogenesis, and possibly insulin secretion and insulin action. Abnormal expression or genetic variations of HSL are associated with human disorders such as obesity, insulin resistance, type 2 diabetes, and hyperlipidemia[1][2].
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Hormone-Sensitive Lipase (HSL) Related Products (3)
Related Products (3)
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Silafluofen
0 ImagesCat. No.: HY-W714217CAS No.: 105024-66-6Silafluofen is a hormone sensitive lipase (HSL) inhibitor. Silafluofen is an insecticide.
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CM002
0 ImagesCat. No.: HY-184895CM002 is a circadian clock activator. CM002 inhibits the lineage commitment and terminal differentiation of preadipocytes by activating the circadian clock, thereby blocking the adipogenesis process driven by Wnt signaling-mediated transcriptional induction. CM002 attenuates lipid storage in a clock-dependent manner via inhibition of the lipogenic program in mature adipocytes. CM002 enhances circadian clock output across various adipose depots in both lean and obese mice through BMAL1/CLOCK-dependent metabolic reprogramming, inhibits adipocyte development and hypertrophy, and improves insulin sensitivity. CM002 can be used in research on obesity and type 2 diabetes.
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Diethylumbelliferyl phosphate
0 ImagesDiethylumbelliferyl phosphate (DEUP) is a broad-spectrum inhibitor of serine esterase and lipases. Diethylumbelliferyl phosphate inhibits cholesteryl ester hydrolase (CEH), adipose triglyceride lipase (ATGL/cytosolic lipase), and retinyl ester hydrolase. Diethylumbelliferyl phosphate blocks the hydrolysis of triglycerides and cholesteryl esters by inhibiting key hydrolases such as CEH and ATGL, thereby inhibiting the mobilization and remodeling of lipid droplet contents, which in turn reduces intracellular reactive oxygen species (ROS) levels and inhibits apoptosis. Diethylumbelliferyl phosphate can be used in research on lipid and cholesterol metabolic diseases and Alzheimer's disease.
