897-83-6
Chemical Structure
Diethylumbelliferyl phosphate
Synonym(s): DEUP
- CAS No.: 897-83-6
- Formula:C14H17O6P
- Molecular Weight:312.25
IUPAC Name: diethyl (4-methyl-2-oxo-2H-chromen-7-yl) phosphate
InChIKey: GHGRYKAFUNNHBG-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C(C)=C1)C=CC(OP(OCC)(OCC)=O)=C2
Biological Activity: Diethylumbelliferyl phosphate (DEUP) is a broad-spectrum inhibitor of serine esterase and lipases. Diethylumbelliferyl phosphate inhibits cholesteryl ester hydrolase (CEH), adipose triglyceride lipase (ATGL/cytosolic lipase), and retinyl ester hydrolase. Diethylumbelliferyl phosphate blocks the hydrolysis of triglycerides and cholesteryl esters by inhibiting key hydrolases such as CEH and ATGL, thereby inhibiting the mobilization and remodeling of lipid droplet contents, which in turn reduces intracellular reactive oxygen species (ROS) levels and inhibits apoptosis. Diethylumbelliferyl phosphate can be used in research on lipid and cholesterol metabolic diseases and Alzheimer's disease[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Diethylumbelliferyl phosphate | 99.2% | Diethylumbelliferyl phosphate (DEUP) is a broad-spectrum inhibitor of serine esterase and lipases. Diethylumbelliferyl phosphate inhibits cholesteryl ester hydrolase (CEH), adipose triglyceride lipase (ATGL/cytosolic lipase), and retinyl ester hydrolase. Diethylumbelliferyl phosphate blocks the hydrolysis of triglycerides and cholesteryl esters by inhibiting key hydrolases such as CEH and ATGL, thereby inhibiting the mobilization and remodeling of lipid droplet contents, which in turn reduces intracellular reactive oxygen species (ROS) levels and inhibits apoptosis. Diethylumbelliferyl phosphate can be used in research on lipid and cholesterol metabolic diseases and Alzheimer's disease. | ||||||||||||||||||||
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References
- [1]. Mau KHT, et al. Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development. Nature communications. 2022 Jul 05;13(1):3861.
- [2]. Marcinkiewicz A, et al. The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion. The Journal of biological chemistry. 2006 Apr 28;281(17):11901-9.
- [3]. Kang SWS, et al. Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American journal of physiology. Cell physiology. 2019 Nov 01;317(5):C942-C952. [Content Brief]
- [4]. Singh R, et al. Autophagy regulates lipid metabolism. Nature. 2009 Apr 30;458(7242):1131-5. [Content Brief]
- [5]. Chung JY, et al. Cholesterol accumulation, lipid droplet formation, and steroid production in Leydig cells: Role of translocator protein (18-kDa). Andrology. 2020 May;8(3):719-730. [Content Brief]
- [6]. García-Giménez J, et al. Fatty acid binding proteins (FABPs) inhibition impairs metabolic homeostasis in renal tubular cells. Nephrol Dial Transplant. 2023;38(Suppl 1):gfad063c_5666.
- [7]. Żbikowska D, et al. Strain- and lineage-specific regulation of lipid droplet metabolism in the mouse blastocyst†. Biology of reproduction. 2026 Aug 18;115(2):469-482. [Content Brief]
- [8]. McGowan SE, et al. Contributions of retinoids to the generation and repair of the pulmonary alveolus. Chest. 2002 May;121(5 Suppl):206S-208S.
- [9]. Simmons C, et al. Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases. Alzheimer's research & therapy. 2014;6(2):15.
- [10]. Choi YS, et al. Diethylumbelliferyl phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein kinase A activation and induction of the steroidogenic acute regulatory protein (StAR).
