3109368-53-5
Chemical Structure
Allo-aca
- CAS No.: 3109368-53-5
- Formula:C48H75N13O15
- Molecular Weight:1074.19
IUPAC Name: (6S,9S,12S,15S,18S,21S,24S)-1-amino-6-((4-(2-amino-2-oxoethyl)-2-oxo-2H-chromen-7-yl)carbamoyl)-24-((2S,3S)-2-amino-3-hydroxybutanamido)-9-(hydroxymethyl)-1-imino-12-isobutyl-18-isopropyl-15-methyl-8,11,14,17,20,23-hexaoxo-21-propyl-2,7,10,13,16,19,22-heptaazaheptacosan-27-oic acid
InChIKey: HBIZXCPYXWQUEB-PPHQEZGGSA-N
SMILES: O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NC1=CC(OC(C=C2CC(N)=O)=O)=C2C=C1)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](O)C)N
Biological Activity: Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Allo-aca | 99.73% | Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models. | ||||||||||||||||||||
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References
- [1]. Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584. [Content Brief]
- [2]. Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13. [Content Brief]
