11-Dehydrodexamethasone
Based on 1 Customer Validation
11-Dehydrodexamethasone, Dexamethasone (HY-14648) derivative, is a substrate for 11β-hydroxysteroid dehydrogenase (11β-HSD) 1/2. 11-Dehydrodexamethasone undergoes conversion to Dexamethasone via reductive activity of 11β-HSD.
For research use only. We do not sell to patients.
- Purity : 99.19%
- CAS No.: 2964-81-0
- Formula: C22H27FO5
- Molecular Weight:390.45
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
11-Dehydrodexamethasone (20 ng; 10 min) acts as a substrate for both 11β-HSD1 (rat liver) and 11β-HSD2 (rat renal cortex, human kidney) isozymes, undergoing conversion to Dexamethasone (HY-14648) with mean conversion rates of 65%, 53.5%, and 69% respectively in the tested tissue homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2964-81-0
-
Appearance Solid
-
Molecular Weight 390.45
-
Formula C22H27FO5
-
Color White to off-white
-
SMILES
F[C@@]12[C@](CCC([C@@]2(C=C3)C)=CC3=O)([H])[C@@]4([H])[C@](CC1=O)([C@](O)([C@@H](C4)C)C(CO)=O)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (256.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5611 mL | 12.8057 mL | 25.6115 mL | 64.0287 mL |
| 5 mM | 0.5122 mL | 2.5611 mL | 5.1223 mL | 12.8057 mL | |
| 10 mM | 0.2561 mL | 1.2806 mL | 2.5611 mL | 6.4029 mL | |
| 15 mM | 0.1707 mL | 0.8537 mL | 1.7074 mL | 4.2686 mL | |
| 20 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2014 mL | |
| 25 mM | 0.1024 mL | 0.5122 mL | 1.0245 mL | 2.5611 mL | |
| 30 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL | 2.1343 mL | |
| 40 mM | 0.0640 mL | 0.3201 mL | 0.6403 mL | 1.6007 mL | |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2806 mL | |
| 60 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0671 mL | |
| 80 mM | 0.0320 mL | 0.1601 mL | 0.3201 mL | 0.8004 mL | |
| 100 mM | 0.0256 mL | 0.1281 mL | 0.2561 mL | 0.6403 mL |
11-Dehydrodexamethasone Related Classifications
HY-W754031 Related Classifications
Powered by Bioz