country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-154916

Copy Link Print Information

13-O-Desmethyl tacrolimus

Name: 13-O-Desmethyl tacrolimus
Brand: MedChemExpress
SKU: HY-154916
Price: 1985.00 USD
Availability: PreOrder

(Synonyms: 13-DMT; 13-O-Demethyl FK 506)

13-O-Desmethyl tacrolimus (13-DMT; 13-O-Demethyl FK 506) is the major metabolite of Tacrolimus (HY-13756) formed via cytochrome P450 3A-mediated biotransformation. The ratio of 13-O-Desmethyl tacrolimus to Tacrolimus serves as a biomarker for myelotoxicity and hepatotoxicity.

For research use only. We do not sell to patients.

CAS No.: 139958-51-3
Formula: C₄₃H₆₇NO₁₂
Molecular Weight:789.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

13-O-Desmethyl tacrolimus Chemical Structure

CAS No.: 139958-51-3

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

¹³O-Desmethyl tacrolimus (0.25-50 ng/mL) is accurately and precisely quantified in in vitro spiked rat kidney tissue homogenates via the validated LC-MS/MS assay, with stable performance through freeze-thaw cycling, 6 hours at room temperature, and 24 hours in the auto-sampler^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Hepatotoxicity Study

Chemical Information

CAS No. 139958-51-3
Molecular Weight 789.99
Formula C₄₃H₆₇NO₁₂
SMILES

CO[C@@H]1[C@@]2([H])O[C@@](C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@@H](/C=C(C[C@@H](C1)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)([C@@H](C[C@@H]2O)C)O
Synonyms

13-DMT; 13-O-Demethyl FK 506
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zegarska J, et al. Evaluation of the Relationship Between Concentrations of Tacrolimus Metabolites, 13-O-Demethyl Tacrolimus and 15-O-Demethyl Tacrolimus, and Clinical and Biochemical Parameters in Kidney Transplant Recipients. Transplant Proc. 2018 Sep;50(7):2235-2239. [Content Brief]

[2]. Kirresh T, et al. Development and validation of a liquid chromatography-mass spectrometric assay for simultaneous determination of tacrolimus and 13-O-desmethyl tacrolimus in rat kidney tissue. Journal of pharmaceutical and biomedical analysis. 2017 Mar 20;136:32-37.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote