15-epi-PGE1
15-epi-PGE1 (15 (R)-Prostaglandin E1; 15-epiprostaglandin E1) is a stereoisomer of PGE1 (HY-B0131), but its biological activity is much lower than that of PGE1. 15-epi-PGE1 is a weak non-competitive inhibitor of human placental 15-hydroxyprostaglandin dehydrogenase (15-PGDH), with an IC50 of 170 μM. 15-epi-PGE1 has low vasodilatory, antihypertensive, and smooth muscle-stimulating activities.
For research use only. We do not sell to patients.
- CAS No.: 20897-91-0
- Formula: C20H34O5
- Molecular Weight:354.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
170 μM (15-PGDH)
In Vitro
15-epi-PGE1 exhibits extremely weak smooth muscle-stimulating activity in isolated rat uterus and guinea pig ileum assays, with relative potencies of 0.008 and 0.02, respectively, compared with natural PGE1 (1.00)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 20897-91-0
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Molecular Weight 354.48
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Formula C20H34O5
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SMILES
OC(CCCCCC[C@@H]1[C@H]([C@@H](CC1=O)O)/C=C/[C@H](O)CCCCC)=O
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Synonyms
15(R)-Prostaglandin E1; 15-Epiprostaglandin E1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. MURAKAMI A, et al. Conformational Analysis of Prostaglandins. III. Study on Active Sites and Conformation-Action Relationship. Chemical and Pharmaceutical Bulletin. 1977 Dec 25;25(12):3155-62. [Content Brief]
[3]. Jarabak J, et al. Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch Biochem Biophys. 1976 Nov;177(1):245-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
15-epi-PGE1 Related Classifications
HY-116096 Related Classifications
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