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Cat. No.: HY-W004464S

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2-(1-Piperazinyl)pyrimidine-d₈

2-(1-Piperazinyl)pyrimidine-d₈ is the deuterated-labeled 2-(1-Piperazinyl)pyrimidine (HY-W004464). 2-(1-Piperazinyl)pyrimidine is an orally effective α₂-adrenoceptor antagonist and 5-HT1A receptor agonist. 2-(1-Piperazinyl)pyrimidine is an in vivo metabolite related to buspirone. 2-(1-Piperazinyl)pyrimidine modulates excitatory synaptic transmission in the hippocampus and the release of monoamine transmitters such as norepinephrine and 5-HT by blocking α2-adrenoceptor and activating 5-HT1A Receptor. 2-(1-Piperazinyl)pyrimidine is used in research on psychiatric disorders such as anxiety and depression.

For research use only. We do not sell to patients.

CAS No.: 1309283-31-5
Formula: C₈H₄D₈N₄
Molecular Weight:172.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

2-(1-Piperazinyl)pyrimidine-d₈ Chemical Structure

CAS No.: 1309283-31-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

α2-adrenergic receptor

5-HT_1A Receptor

All Adrenergic Receptor Isoforms :

All 5-HT Receptor Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1309283-31-5
Unlabeled CAS 20980-22-7
Molecular Weight 172.26
Formula C₈H₄D₈N₄
SMILES

[2H]C1([2H])C([2H])([2H])NC([2H])([2H])C([2H])([2H])N1C2=NC=CC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gobbi M, et al. Antagonist properties of 1-(2-pyrimidinyl)piperazine at presynaptic alpha 2-adrenoceptors in the rat brain. European journal of pharmacology. 1990 May 03;180(1):183-6.

[2]. Bianchi G, et al. The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP). European journal of pharmacology. 1988 Jul 14;151(3):365-71.

[3]. Gower AJ, et al. Alpha 2-adrenoceptor antagonist activity may account for the effects of buspirone in an anticonflict test in the rat. European journal of pharmacology. 1988 Oct 11;155(1-2):129-37.

[4]. Zhang L, et al. Carboxy group derivatization for enhanced electron-transfer dissociation mass spectrometric analysis of phosphopeptides. Proteomics. 2009 Aug;9(16):4093-7.

[5]. Manahan-Vaughan D, et al. The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT1A receptors. European journal of pharmacology. 1995 Dec 29;294(2-3):617-24. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2-(1-Piperazinyl)pyrimidine-d8

All Adrenergic Receptor Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Description

IC50 & Target

Application

Chemical Information

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References

Calculators

Help & FAQs

2-(1-Piperazinyl)pyrimidine-d8 Related Classifications

HY-W004464S Related Classifications

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2-(1-Piperazinyl)pyrimidine-d₈

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