2,6-F2-PTM-S-DABO
2,6-F2-PTM-S-DABO is a non-nucleoside inhibitor of HIV-1 Reverse transcriptase, with an ID50 of 0.002 μM against HIV-1 RT. 2,6-F2-PTM-S-DABO exhibits anti-HIV-1 activity.
For research use only. We do not sell to patients.
- Formula: C20H18F2N2O2S2
- Molecular Weight:420.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | EC50 |
0.0008 μM
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Antiviral activity against WT HIV-1 NL4-3 in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against WT HIV-1 NL4-3 in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
|
42825139 |
| MT4 | EC50 |
0.003 μM
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Antiviral activity against mutant HIV-1 IRLL98 in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against mutant HIV-1 IRLL98 in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
|
42825139 |
| MT4 | EC50 |
0.54 μM
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Antiviral activity against mutant HIV-1 Y181C in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against mutant HIV-1 Y181C in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
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42825139 |
| MT4 | EC50 |
1 μM
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Antiviral activity against mutant HIV-1 Y188L in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against mutant HIV-1 Y188L in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
|
42825139 |
| MT4 | EC50 |
0.009 μM
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Antiviral activity against mutant HIV-1 K103N in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against mutant HIV-1 K103N in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
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42825139 |
| MT4 | EC50 |
0.062 μM
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Antiviral activity against mutant HIV-1 K103N+Y181C in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
Antiviral activity against mutant HIV-1 K103N+Y181C in MT-4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT method.
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42825139 |
| MT4 | CC50 |
59 μM
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Cytotoxicity against mock-infected MT-4 cells assessed as 50% reduction in viability after 5 days by MTT method; CC50 >59 μM.
Cytotoxicity against mock-infected MT-4 cells assessed as 50% reduction in viability after 5 days by MTT method; CC50 >59 μM.
|
42825139 |
In Vitro
2,6-F2-PTM-S-DABO (20 min) inhibits WT HIV-1 RT with an ID50 of 0.002 μM and maintains single-digit nanomolar to low micromolar potency against NNRTI-resistant RT variants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 420.50
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Formula C20H18F2N2O2S2
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SMILES
COC1=CC=C(C=C1)SCSC2=NC(CC3=C(C=CC=C3F)F)=C(C(N2)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,6-F2-PTM-S-DABO Related Classifications
HY-189963 Related Classifications
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