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Cat. No.: HY-100013

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2-PCCA

2-PCCA is a racemic form of the GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

For research use only. We do not sell to patients.

CAS No.: 1984859-71-3
Formula: C₃₀H₃₇N₃O
Molecular Weight:455.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-PCCA Chemical Structure

CAS No.: 1984859-71-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
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References
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Biological Activity

Description

2-PCCA is a racemic form of the GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC₅₀ of 116 nM in HEK293 cells.

IC₅₀ & Target

EC50: 116 nM (GPR88 receptor, HEK293 cells)^[1]

In Vitro

2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC₅₀ of 116 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2-PCCA (0.1–3.2 mg/kg, intraperitoneal injection) dose-dependently reduces kinetic activity in rats. 2-PCCA (1–3.2 mg/kg, intraperitoneal injection) does not produce a discriminative stimulus effect in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1984859-71-3
Molecular Weight 455.63
Formula C₃₀H₃₇N₃O
SMILES

CC[C@H](C)[C@H](N)CN(C1=CC=C(C2=CC=C(C=C2)CCC)C=C1)C(C3C(C4=CC=CC=N4)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li JX, et al. The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. Eur J Pharmacol. 2013 Jan 5;698(1-3):272-7. [Content Brief]

[2]. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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