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Cat. No.: HY-W750559

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2'-O-MB-cAMP

Name: 2'-O-MB-cAMP
Brand: MedChemExpress
SKU: HY-W750559
Availability: PreOrder

(Synonyms: 2'-O-Monobutyryl cyclic AMP)

2'-O-MB-cAMP (2'-O-Monobutyryl cyclic AMP) is an inactive analog of Cyclic AMP. 2'-O-MB-cAMP serves as a reference standard in FAB/MIKE mass spectrometry for the characterization of butyryl derivatives of cyclic nucleotides. 2'-O-MB-cAMP does not induce differentiation or upregulate Nm23-R1 in glioma cells. 2'-O-MB-cAMP can be used as a negative control cAMP analog for glioma-related research.

For research use only. We do not sell to patients.

CAS No.: 15392-98-0
Formula: C₁₄H₁₈N₅O₇P
Molecular Weight:399.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2'-O-MB-cAMP Chemical Structure

CAS No.: 15392-98-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

In Vitro

Anti-cancerCell Cycle Regulation

Anti-cancer

Cell Cycle Regulation

2'-O-MB-cAMP (1 mM; 48 h), used as a control, does not upregulate Nm23-R1 expression in rat C6 glioma cells, nor does it induce glioma cell differentiation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15392-98-0
Molecular Weight 399.30
Formula C₁₄H₁₈N₅O₇P
SMILES

CCCC(O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@]4([H])[C@@]1([H])OP(O)(OC4)=O)=O
Synonyms

2'-O-Monobutyryl cyclic AMP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Scott SP, et al. Mapping ligand interactions with the hyperpolarization activated cyclic nucleotide modulated (HCN) ion channel binding domain using a soluble construct. Biochemistry. 2007 Aug 21;46(33):9417-31.

[2]. Newton R P, et al. Identification of butyryl derivatives of cyclic nucleotides by positive ion fast atom bombardment mass spectrometry and mass‐analysed ion kinetic energy spectrometry[J]. Organic mass spectrometry, 1989, 24(8): 679-688.

[3]. Roymans D, et al. Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma. Experimental cell research. 2000 Nov 25;261(1):127-38.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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