2-Amino-5-fluoropyridine
Based on 1 Customer Validation
2-Amino-5-fluoropyridine is a pharmaceutical intermediate. 2-Amino-5-fluoropyridine can serve as a hinge-binding group of 2-Aminopyridine (HY-Y0174), resulting in a significant loss of PI3Kβ activity.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 21717-96-4
- Formula: C5H5FN2
- Molecular Weight:112.11
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 21717-96-4
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Appearance Solid
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Molecular Weight 112.11
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Formula C5H5FN2
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Color Off-white to yellow
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SMILES
NC1=NC=C(F)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Woll MG, et al. Discovery and optimization of small molecule splicing modifiers of survival motor neuron 2 as a treatment for spinal muscular atrophy. Journal of medicinal chemistry. 2016 Jul 14;59(13):6070-85. [Content Brief]
[2]. Maeda DY, et al. Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. Journal of medicinal chemistry. 2014 Oct 23;57(20):8378-97. [Content Brief]
[3]. Moslin R, et al. Identification of -Methyl Nicotinamide and -Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). Journal of medicinal chemistry. 2019 Oct 24;62(20):8953-8972. [Content Brief]
[4]. Perreault S, et al. Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif. ACS medicinal chemistry letters. 2020 Jun 11;11(6):1236-1243. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)