2-Chloro-5-cyanopyridine
Based on 1 Customer Validation
2-Chloro-5-cyanopyridine is a chlorocyanopyridine synthesis intermediate that can be used in the synthesis of JAK3 inhibitors.
For research use only. We do not sell to patients.
- Purity : 99.82%
- CAS No.: 33252-28-7
- Formula: C6H3ClN2
- Molecular Weight:138.56
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W015626
2,5-DichloropyridineBiochemical Reagent -
HY-W007536
2,6-Dichloroisonicotinic acidBiochemical Reagent -
HY-33868
3-Amino-4-chloropyridineBiochemical Reagent -
HY-65003
2-Chloroisonicotinic acidDrug Intermediate -
HY-W004860
4-Bromopicolinic acidBiochemical Reagent -
HY-W015627
3,5-DichloropyridineDrug Intermediate -
HY-32833
2-Chloro-3-pyridinolBiochemical Reagent -
HY-W010174
2-Chloro-4-nitropyridineDrug Intermediate -
HY-W007353
2-Bromo-5-methylpyridineBiochemical Reagent -
HY-W002593
2-Acetyl-6-bromopyridineBiochemical Reagent -
HY-W007712
2-Bromo-3-methylpyridineDrug Intermediate -
HY-75420
5-Bromo-3-methylpyridin-2-amineIntermediate
Biological Activity
Description
In Vitro
2-Chloro-5-cyanopyridine undergoes nucleophilic aromatic substitution with a deprotected piperidinylamine nicotinamide intermediate under basic conditions, introducing the 5-cyanopyridin-2-yl group into the 4,6-diaminonicotinamide scaffold to afford low-nanomolar JAK3 inhibitors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 33252-28-7
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Appearance Solid
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Molecular Weight 138.56
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Formula C6H3ClN2
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Color White to light yellow
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SMILES
N#CC1=CN=C(Cl)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (721.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2171 mL | 36.0855 mL | 72.1709 mL | 180.4273 mL |
| 5 mM | 1.4434 mL | 7.2171 mL | 14.4342 mL | 36.0855 mL | |
| 10 mM | 0.7217 mL | 3.6085 mL | 7.2171 mL | 18.0427 mL | |
| 15 mM | 0.4811 mL | 2.4057 mL | 4.8114 mL | 12.0285 mL | |
| 20 mM | 0.3609 mL | 1.8043 mL | 3.6085 mL | 9.0214 mL | |
| 25 mM | 0.2887 mL | 1.4434 mL | 2.8868 mL | 7.2171 mL | |
| 30 mM | 0.2406 mL | 1.2028 mL | 2.4057 mL | 6.0142 mL | |
| 40 mM | 0.1804 mL | 0.9021 mL | 1.8043 mL | 4.5107 mL | |
| 50 mM | 0.1443 mL | 0.7217 mL | 1.4434 mL | 3.6085 mL | |
| 60 mM | 0.1203 mL | 0.6014 mL | 1.2028 mL | 3.0071 mL | |
| 80 mM | 0.0902 mL | 0.4511 mL | 0.9021 mL | 2.2553 mL | |
| 100 mM | 0.0722 mL | 0.3609 mL | 0.7217 mL | 1.8043 mL |
2-Chloro-5-cyanopyridine Related Classifications
HY-59197 Related Classifications
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