2-Methoxyestradiol-13C,d3
2-Methoxyestradiol-13C,d3 (2-ME2-13C,d3; NSC-659853-13C,d3) is the deuterated, 13C-labeled 2-Methoxyestradiol (HY-12033). 2-Methoxyestradiol (2-ME2; NSC-659853) is an endogenous steroid metabolite generated from 17β-estradiol, possessing various activities such as antitumor and antiangiogenic effects. 2-Methoxyestradiol competitively binds to the colchicine-binding site of tubulin (tubulin), interfering with microtubule assembly dynamics. 2-Methoxyestradiol inhibits CYP1A1/CYP1B1, HIF-1α/2α, and superoxide dismutase, activates the JNK signaling pathway, elevates ROS levels, and induces cell cycle arrest and apoptosis (apoptosis). 2-Methoxyestradiol is used in cancer-related research, such as breast cancer, prostate cancer, and multiple myeloma.
For research use only. We do not sell to patients.
- CAS No.: 1217470-09-1
- Formula: C1813CH23D3O3
- Molecular Weight:306.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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Aromatase |
CYP1A1 |
CYP1B1 |
Caspase-8 |
Caspase-9 |
HIF-1α |
HIF-2α |
Caspase 3 |
ERα 21 nM (Ki) |
ERβ 417 nM (Ki) |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217470-09-1
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Unlabeled CAS 362-07-2
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Molecular Weight 306.42
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Formula C1813CH23D3O3
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SMILES
C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(O[13C]([2H])([2H])[2H])=C(O)C=C4CC3
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Synonyms
2-ME2-13C,d33; NSC-659853-13C,d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Mooberry SL, et al. Mechanism of action of 2-methoxyestradiol: new developments. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2003 Dec;6(6):355-61. [Content Brief]
[3]. LaVallee TM, et al. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer research. 2002 Jul 01;62(13):3691-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methoxyestradiol-13C,d3 Related Classifications
HY-12033S Related Classifications
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Keywords
- 2-Methoxyestradiol-13C,d3
- 1217470-09-1
- 2-ME2-13C,d33
- NSC-659853-13C,d3
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Microtubule/Tubulin
- HIF/HIF Prolyl-Hydroxylase
- Cytochrome P450
- JNK
- Caspase
- Estrogen Receptor/ERR
- Reactive Oxygen Species (ROS)
- Apoptosis
- Autophagy
- CYP1A1
- CYP1B1
- G2-M arrest
- HIF-1α
- antiangiogenesis
- apoptosis
- aromatase inhibitor
- estrogen receptors
- superoxide dismutase
- tubulin inhibitor
- Inhibitor
- inhibitor
- inhibit