2-Methoxyestradiol-d5
Based on 1 Customer Validation
2-Methoxyestradiol-d5 (2-ME2-d5; NSC-659853-d5) is the deuterated-labeled 2-Methoxyestradiol (HY-12033). 2-Methoxyestradiol (2-ME2; NSC-659853) is an endogenous steroid metabolite generated from 17β-estradiol, possessing various activities such as antitumor and antiangiogenic effects. 2-Methoxyestradiol competitively binds to the colchicine-binding site of tubulin (tubulin), interfering with microtubule assembly dynamics. 2-Methoxyestradiol inhibits CYP1A1/CYP1B1, HIF-1α/2α, and superoxide dismutase, activates the JNK signaling pathway, elevates ROS levels, and induces cell cycle arrest and apoptosis (apoptosis). 2-Methoxyestradiol is used in cancer-related research, such as breast cancer, prostate cancer, and multiple myeloma.
For research use only. We do not sell to patients.
- Purity : 98.67%
- CAS No.: 358731-34-7
- Formula: C19H21D5O3
- Molecular Weight:307.44
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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Aromatase |
CYP1A1 |
CYP1B1 |
Caspase-8 |
Caspase-9 |
HIF-1α |
HIF-2α |
Caspase 3 |
ERα 21 nM (Ki) |
ERβ 417 nM (Ki) |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 358731-34-7
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Unlabeled CAS 362-07-2
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Appearance Solid
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Molecular Weight 307.44
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Formula C19H21D5O3
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Color White to off-white
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SMILES
C[C@@]12[C@](CC([2H])([2H])[C@]2([2H])O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C([2H])C(OC)=C(O)C([2H])=C4CC3
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Synonyms
2-ME2-d5; NSC-659853-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[2]. Mooberry SL, et al. Mechanism of action of 2-methoxyestradiol: new developments. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2003 Dec;6(6):355-61. [Content Brief]
[3]. LaVallee TM, et al. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer research. 2002 Jul 01;62(13):3691-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methoxyestradiol-d5 Related Classifications
HY-12033S2 Related Classifications
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Keywords
- 2-Methoxyestradiol-d5
- 358731-34-7
- 2-ME2-d5
- NSC-659853-d5
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Microtubule/Tubulin
- HIF/HIF Prolyl-Hydroxylase
- Cytochrome P450
- JNK
- Caspase
- Estrogen Receptor/ERR
- Reactive Oxygen Species (ROS)
- Apoptosis
- Autophagy
- CYP1A1
- CYP1B1
- G2-M arrest
- HIF-1α
- antiangiogenesis
- apoptosis
- aromatase inhibitor
- estrogen receptors
- superoxide dismutase
- tubulin inhibitor
- Inhibitor
- inhibitor
- inhibit