2-Methoxyestradiol (Standard)
2-Methoxyestradiol (Standard) (2-ME2 (Standard); NSC-659853 (Standard)) is the analytical standard of 2-Methoxyestradiol (HY-12033). This product is intended for research and analytical applications. 2-Methoxyestradiol (2-ME2; NSC-659853) is an endogenous steroid metabolite generated from 17β-estradiol, possessing various activities such as antitumor and antiangiogenic effects. 2-Methoxyestradiol competitively binds to the colchicine-binding site of tubulin (tubulin), interfering with microtubule assembly dynamics. 2-Methoxyestradiol inhibits CYP1A1/CYP1B1, HIF-1α/2α, and superoxide dismutase, activates the JNK signaling pathway, elevates ROS levels, and induces cell cycle arrest and apoptosis (apoptosis). 2-Methoxyestradiol is used in cancer-related research, such as breast cancer, prostate cancer, and multiple myeloma.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 362-07-2
- Formula: C19H26O3
- Molecular Weight:302.41
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
-
HY-12033
2-MethoxyestradiolSteroid Metabolite -
HY-N0164
MatrineAnticancer Agent -
HY-N0005
Curcuminp300 Histone Acetylatransferase Inhibitor -
HY-10529
Betulinic acidApoptosis Inducer -
HY-N0848
EpibrassinolideApoptosis Inducer -
HY-12867
PT-2385HIF-2α Inhibitor -
HY-B0011
DocetaxelTubulin Stabilizer -
HY-N0005R
Curcumin (Standard)Standard of Curcumin -
HY-13671
LW6Apoptosis Inducer -
HY-15836
BAY 87-2243HIF-1 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 362-07-2
-
Molecular Weight 302.41
-
Formula C19H26O3
-
SMILES
OC1=CC2=C([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC2)[H])[H])O)C)[H])C=C1OC
-
Synonyms
2-ME2 (Standard); NSC-659853 (Standard)
-
Structure Classification
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Mooberry SL, et al. Mechanism of action of 2-methoxyestradiol: new developments. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2003 Dec;6(6):355-61. [Content Brief]
[3]. LaVallee TM, et al. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer research. 2002 Jul 01;62(13):3691-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methoxyestradiol (Standard) Related Classifications
HY-12033R Related Classifications
Powered by Bioz
Keywords
- 2-Methoxyestradiol (Standard)
- 362-07-2
- 2-ME2 (Standard)
- NSC-659853 (Standard)
- Reference Standards
- Endogenous Metabolite
- Microtubule/Tubulin
- HIF/HIF Prolyl-Hydroxylase
- Cytochrome P450
- JNK
- Caspase
- Estrogen Receptor/ERR
- Reactive Oxygen Species (ROS)
- Apoptosis
- Autophagy
- CYP1A1
- CYP1B1
- G2-M arrest
- HIF-1α
- antiangiogenesis
- apoptosis
- aromatase inhibitor
- estrogen receptors
- superoxide dismutase
- tubulin inhibitor
- Inhibitor
- inhibitor
- inhibit