23ME-00610

23ME-00610 binds to purified recombinant hCD200R1 isoforms and haplotypes with high affinity^[1].
23ME-00610 (serial dilutions) binds to CD200R1 on the surface of primary CD4⁺ T cells with a mean EC₅₀ of 0.34 nM; it binds to CD200R1 on the surface of CD8⁺ T cells with a representative EC₅₀ of 0.32 nM; and it binds to CD200R1 on the surface of monocyte-derived dendritic cells with a mean EC₅₀ of 0.55 nM^[1].
23ME-00610 blocks the binding of CD200:CD200R1 in the ELISA system, with an IC₅₀ value of 0.34 nM^[1].
23ME-00610 (serial dilutions of 23ME-00610; 30 min) displaces pre-bound CD200 from U937 cells expressing CD200R1, with an EC₅₀ value ranging from 0.32 to 1.04 nM^[1].
Serial dilutions of 23ME-00610 inhibit CD200-induced recruitment of DOK2 to CD200R1 in the Jurkat reporter cell system, with a mean IC₅₀ of 0.02 nM^[1].
23ME-00610 (50 nM; 24 h for IL-2, 72 h for IFNγ) fully restores CD200-suppressed IL-2 production at a concentration of 50 nM in chronically stimulated primary CD3+ T cells, and restores CD200-suppressed IFNγ secretion with a mean EC₅₀ of 0.055 nM^[1].
23ME-00610 (0.08-20 nM; 120 h) enhances the killing effect of primary PBMCs on CD200-expressing COV-644-GFP ovarian cancer cells, with a mean EC₅₀ of 2.09 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.