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Cat. No.: HY-N21727

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3-Hydroxyhericenone F

3-Hydroxyhericenone F is a neuroprotective agent. Hydroxyhericenone F protects cells against NaN₃-induced toxicity, ultrastructural changes, and alterations in mitochondrial respiratory chain complexes. 3-Hydroxyhericenone F decreases intracellular ROS and calcium levels, increases mitochondrial membrane potential and ATP levels, attenuates NaN₃-induced changes in apoptosis-related proteins, and protects neuronal cells from endoplasmic reticulum stress-dependent cell death. 3-Hydroxyhericenone F can be used in research related to cancer, Alzheimer's disease, and neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 1094030-07-5
Formula: C₃₅H₅₄O₇
Molecular Weight:586.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-Hydroxyhericenone F Chemical Structure

CAS No.: 1094030-07-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Anti-cancerMitochondrial FunctionApoptosisEndoplasmic Reticulum Stress

Anti-cancer

3-Hydroxyhericenone F exhibits a LibDockScore as high as 180 and forms four stable hydrogen bond interactions with residues LYS321 and Thr72 of human BACE1, indicating its potent BACE1 inhibitory activity^[1].
3-Hydroxyhericenone F (0.05-2.00 µg/mL; 2-24 h) significantly protects PC12 cells against NaN₃-induced cytotoxicity and restores cell viability^[1].
3-Hydroxyhericenone F (0.05-1.50 µg/mL; 2-24 h) significantly increases mitochondrial complex I, V, and ATP levels in NaN₃-induced PC12 cells^[1].
3-Hydroxyhericenone F (0.5-1.50 µg/mL; 2-24 h) reverses the NaN₃-induced upregulation of p21, NF-κB p65, and PARP1 mRNA expression in PC12 cells^[1].
3-Hydroxyhericenone F (0.05-1.50 µg/mL; 2-24 h) downregulates BACE1, p-Tau, and Aβ₄₂ protein expression and reverses NaN₃-induced expression of p21, NF-κB p65, and PARP1 in PC12 cells^[1].

Mitochondrial Function

Anti-cancer

3-Hydroxyhericenone F (0.05-1.50 µg/mL; 2-24 h) reverses NaN₃-induced calcium overload and mitochondrial membrane potential collapse, and reduces ROS levels in PC12 cells^[1].

Anti-cancer

Apoptosis

3-Hydroxyhericenone F (0.05-1.50 µg/mL; 2-24 h) reverses NaN₃-induced changes in COX I, COX II, NF-κB, Caspase-3, and Caspase-9 protein levels in PC12 cells^[1].

Mitochondrial Function

3-Hydroxyhericenone F (0.05-1.50 µg/mL; 2 h) attenuates NaN₃-induced cellular and mitochondrial morphological damage in PC12 cells and increases fluorescence intensity^[1].

Endoplasmic Reticulum Stress

3-Hydroxyhericenone F (0.1-10 µg/mL; 24 h) significantly and dose-dependently protects Neuro2a cells from Tunicamycin (HY-A0098)- or Thapsigargin (HY-13433)-induced endoplasmic reticulum stress-dependent cell death^[2].
3-Hydroxyhericenone F (1.7-17 μM; 24 h) exhibits significant protective activity against TG-induced endoplasmic reticulum stress and moderate protective activity against TM-induced endoplasmic reticulum stress in Neuro2a cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

0.05, 1.00, and 2.00 µg/mL
Incubation Time:

2 h (co-incubation); 24 h (NaN₃ exposure)
Result:

Increased cell viability to 63%, 85%, and 106% of the control value at concentrations of 0.05, 1.00, and 2.00 µg/mL, respectively, compared with the NaN₃ group.

Real Time qPCR^[1]

Cell Line:

PC12 cells
Concentration:

0.5, 1.00, and 1.50 µg/mL
Incubation Time:

2 h (pretreatment); 4 and 8 h (NaN₃ exposure)
Result:

Reversed the increased mRNA expression trends of PARP1, p21, and NF-κB p65, notably at 1.50 µg/mL where mRNA expression was reversed to normal levels.

Western Blot Analysis^[1]

Cell Line:

PC12 cells
Concentration:

0.05, 1.00, and 1.50 µg/mL
Incubation Time:

2 h (pretreatment); 4, 8, and 24 h (NaN₃ exposure)
Result:

Decreased BACE1, p-Tau, and Aβ₄₂ protein expression in all three treatment groups compared with the normal group.
Reversed p21, NF-κB p65, and PARP1 protein expression compared with the model group.

ELISA Assay^[1]

Cell Line:

PC12 cells
Concentration:

0.05, 1.00, and 1.50 µg/mL
Incubation Time:

2 h (pretreatment); 24 h (NaN₃ exposure)
Result:

Reversed the protein expression of COX I, COX II, NF-κB, Caspase-3, and Caspase-9 approximately to normal levels.

Immunofluorescence^[1]

Cell Line:

PC12 cells
Concentration:

0.05, 1.00, and 1.50 µg/mL
Incubation Time:

2 h (pretreatment); 24 h (NaN₃ exposure)
Result:

Increased fluorescence intensities to 43.15%, 61.27%, and 86.78% of the control value at 0.05, 1.00, and 1.50 µg/mL, respectively.
Significantly alleviated NaN₃-induced ultrastructural changes.

Cell Viability Assay^[2]

Cell Line:

Neuro2a
Concentration:

0.1, 1 and 10 µg/mL
Incubation Time:

24 h
Result:

Showed significant protective activity against both tunicamycin- and thapsigargin-induced toxicity in a dose-dependent manner.

Related Protocols :

Chemical Information

CAS No. 1094030-07-5
Molecular Weight 586.81
Formula C₃₅H₅₄O₇
SMILES

C(=O)C1=C2C(=C(OC)C=C1COC(CCCCCCCCCCCCCCC)=O)C[C@@]([C@](CC(C=C(C)C)=O)(C)O)(O2)[H]
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Diling C, et al. Docking studies and biological evaluation of a potential β-secretase inhibitor of 3-hydroxyhericenone F from Hericium erinaceus. Frontiers in pharmacology. 2017 May 12;8:219.

[2]. Ueda K, et al. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorganic & medicinal chemistry. 2008 Nov 01;16(21):9467-70.

[3]. Kobayashi S, et al. Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A− C and their derivatives. Tetrahedron Letters. 2018 May 2;59(18):1733-6.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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3-Hydroxyhericenone F

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

3-Hydroxyhericenone F Related Classifications

HY-N21727 Related Classifications

Bioz

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