4,4'-Dichlorobenzophenone
Based on 1 publication(s) in Google Scholar
4,4'-Dichlorobenzophenone (Bis (4-chlorophenyl) ketone) is an ERα/ERβ agonist with IC50 values of 40.86 μM and 24.11 μM, respectively. 4,4'-Dichlorobenzophenone induces ER-dependent cancer cell proliferation after long-term exposure. 4,4'-Dichlorobenzophenone can be used for research on breast cancer.
For research use only. We do not sell to patients.
- Purity : 99.93%
- CAS No.: 90-98-2
- Formula: C13H8Cl2O
- Molecular Weight:251.11
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 4,4'-Dichlorobenzophenone
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Biological Activity
Description
IC50 & Target
[2]|
ERα 40.86 μM (IC50) |
ERβ 24.11 μM (IC50) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MVLN cells
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Concentration:20 μM
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Incubation Time:48 h
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Result:Showed a significant effect on MVLN cell viability at 20 μM.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 90-98-2
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Appearance Solid
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Molecular Weight 251.11
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Formula C13H8Cl2O
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Color Off-white to pink
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SMILES
ClC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1
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Synonyms
Bis(4-chlorophenyl) ketone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
Solvent & Solubility
In Vitro:
DMSO : 20 mg/mL (79.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9823 mL | 19.9116 mL | 39.8232 mL | 99.5580 mL |
| 5 mM | 0.7965 mL | 3.9823 mL | 7.9646 mL | 19.9116 mL | |
| 10 mM | 0.3982 mL | 1.9912 mL | 3.9823 mL | 9.9558 mL | |
| 15 mM | 0.2655 mL | 1.3274 mL | 2.6549 mL | 6.6372 mL | |
| 20 mM | 0.1991 mL | 0.9956 mL | 1.9912 mL | 4.9779 mL | |
| 25 mM | 0.1593 mL | 0.7965 mL | 1.5929 mL | 3.9823 mL | |
| 30 mM | 0.1327 mL | 0.6637 mL | 1.3274 mL | 3.3186 mL | |
| 40 mM | 0.0996 mL | 0.4978 mL | 0.9956 mL | 2.4889 mL | |
| 50 mM | 0.0796 mL | 0.3982 mL | 0.7965 mL | 1.9912 mL | |
| 60 mM | 0.0664 mL | 0.3319 mL | 0.6637 mL | 1.6593 mL |
4,4'-Dichlorobenzophenone Related Classifications
HY-W011918 Related Classifications
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