4-Isopropyl-3-methylphenol
Based on 1 Customer Validation
4-Isopropyl-3-methylphenol acts as a biofilm inhibitor, Antibacterial agent, Antifungal agent, and Acaricide. 4-Isopropyl-3-methylphenol reduces the expression levels of biofilm-associated gtfB, gtfD, and gtfC genes. 4-Isopropyl-3-methylphenol disrupts ion and redox homeostasis in fungal cells, and its combination with Octylgallate enhances antifungal activity. 4-Isopropyl-3-methylphenol exhibits fumigant toxicity and direct contact toxicity against Dermatophagoides farinae and Dermatophagoides pteronyssinus. 4-Isopropyl-3-methylphenol is applicable to research related to dental caries and Aspergillus infections/contamination.
For research use only. We do not sell to patients.
- CAS No.: 3228-02-2
- Formula: C10H14O
- Molecular Weight:150.22
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Storage:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[3]|
Mite |
In Vitro
4-Isopropyl-3-methylphenol (100 μg/mL; 4 h) significantly downregulates the gene expression of gtfB, gtfC, and gtfD in Streptococcus mutans JCM 5705[1].
4-Isopropyl-3-methylphenol targets cellular ion and redox homeostasis, as vacuolar (vph2Δ, vma1Δ) and cytoplasmic superoxide dismutase (sod1Δ) mutant strains of Saccharomyces cerevisiae show higher sensitivity to it than other tested yeast strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Streptococcus mutans JCM 5705
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Concentration:100 μg/mL
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Incubation Time:4 h
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Result:Downregulated gtfB, gtfC, and gtfD gene expression by 62%, 70%, and 63% respectively.
In Vivo
4-Isopropyl-3-methylphenol (single exposure; 24 h) exhibits fumigant acaricidal activity against adult D. pteronyssinus, with an LD50 of 1.03 μg/cm2, and is 9.54 times as potent as Benzyl benzoate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:adult (7-10 days old)[3]
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Dosage:Not specified
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Administration:fumigant; single exposure; 24 hours
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Result:Exhibited an LD50 value of 0.78 μg/cm2 for fumigant toxicity.
Showed a relative toxicity of 13.82 compared to benzyl benzoate.
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Animal Model:adult (7-10 days old)[3]
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Dosage:Not specified
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Administration:fumigant; single exposure; 24 hours
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Result:Exhibited an LD50 value of 1.03 μg/cm2 for fumigant toxicity.
Showed a relative toxicity of 9.54 compared to benzyl benzoate.
Chemical Information
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CAS No. 3228-02-2
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Appearance Solid
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Molecular Weight 150.22
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Formula C10H14O
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SMILES
OC1=CC=C(C(=C1)C)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
References
[1]. Korenaga A, et al. Synergetic inhibitory effect of isopropyl methylphenol-based agents on biofilm formation by Streptococcus mutans. PloS one. 2024;19(9):e0310926. [Content Brief]
[3]. Jeon JH, et al. Contact and fumigant toxicities of 3-methylphenol isolated from Ostericum koreanum and its derivatives against house dust mites. Journal of agricultural and food chemistry. 2012 Dec 19;60(50):12349-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Isopropyl-3-methylphenol Related Classifications
HY-W028720 Related Classifications
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