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Cat. No.: HY-158685A

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(4R,5S)-RG7112D

(4R,5S)-RG7112D is an isomer of RG7112D (HY-158685). The IC₅₀ values of RG7112D for inhibiting MDM2-p53 and VHL-HIF1α are 11 nM and >10000 nM, respectively. (4R,5S)-RG7112D can be used in studies related to PROTAC synthesis, for example, serving as the target protein ligand of (4R,5S)-YX-02-030 (HY-158684A).

For research use only. We do not sell to patients.

Formula: C₃₆H₄₂Cl₂N₄O₄
Molecular Weight:665.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(4R,5S)-RG7112D Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

(4R,5S)-RG7112D acts as a target protein ligand for (4R,5S)-YX-02-030 (HY-158684A). (4R,5S)-YX-02-030 is an isomer of YX-02-030 (HY-158684). YX-02-030 is a VHL-dependent MDM2 PROTAC degrader with a K_d value of 35 nM; it inhibits the binding of MDM2-p53 and VHL-HIF1α, with corresponding IC₅₀ values of 63 nM and 1350 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 665.65
Formula C₃₆H₄₂Cl₂N₄O₄
SMILES

O=C(O)CN1CCN(C(N2[C@@](C)(C3=CC=C(Cl)C=C3)[C@@](C)(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Adams CM, et al. Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer. Cancer discovery. 2023 May 04;13(5):1210-1229. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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