5-Fluoro-lenalidomide
5-Fluoro-lenalidomide is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. 5-Fluoro-lenalidomide can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- CAS No.: 1918158-58-3
- Formula: C13H12FN3O3
- Molecular Weight:277.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1918158-58-3
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Appearance Solid
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Molecular Weight 277.26
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Formula C13H12FN3O3
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Color Off-white to gray
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SMILES
O=C1NC(=O)C(N2C(=O)C=3C=C(F)C=C(N)C3C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (45.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (244 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6067 mL | 18.0336 mL | 36.0672 mL | 90.1681 mL |
| 5 mM | 0.7213 mL | 3.6067 mL | 7.2134 mL | 18.0336 mL | |
| 10 mM | 0.3607 mL | 1.8034 mL | 3.6067 mL | 9.0168 mL | |
| 15 mM | 0.2404 mL | 1.2022 mL | 2.4045 mL | 6.0112 mL | |
| 20 mM | 0.1803 mL | 0.9017 mL | 1.8034 mL | 4.5084 mL | |
| 25 mM | 0.1443 mL | 0.7213 mL | 1.4427 mL | 3.6067 mL | |
| 30 mM | 0.1202 mL | 0.6011 mL | 1.2022 mL | 3.0056 mL | |
| 40 mM | 0.0902 mL | 0.4508 mL | 0.9017 mL | 2.2542 mL |
5-Fluoro-lenalidomide Related Classifications
HY-W875713 Related Classifications
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