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Cat. No.: HY-N20684

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6-Methoxybritannilactone

6-Methoxybritannilactone is an inhibitor of NO production with an EC₅₀ of 3.2 μM. 6-Methoxybritannilactone can be used in the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 2866266-54-6
Formula: C₁₆H₂₄O₄
Molecular Weight:280.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

6-Methoxybritannilactone Chemical Structure

CAS No.: 2866266-54-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

6-Methoxybritannilactone is an inhibitor of NO production with an EC₅₀ of 3.2 μM. 6-Methoxybritannilactone can be used in the research of neurodegenerative diseases^[1].

In Vitro

Innate ImmunityOxidative StressOthers

Innate Immunity

6-Methoxybritannilactone inhibits NO production in LPS (HY-D1056)-stimulated BV-2 microglia, with an EC₅₀ of 3.2 μM, and does not induce significant cytotoxicity at a concentration of 10 μM^[1].

Oxidative Stress

6-Methoxybritannilactone (Compound 4) (5 μM; 24 h) does not significantly protect PC12 cells against H₂O₂-induced injury^[1].

Others

6-Methoxybritannilactone (5 μM; 24 h) fails to significantly protect PC12 cells against 6-OHDA (HY-B1081)-induced injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

5 μM
Incubation Time:

24 h (pre-incubation prior to H₂O₂ treatment)
Result:

Exhibited no obvious cytotoxicity (growth inhibition <10%).
Did not show a significant protective effect against H₂O₂-induced damage.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

5 μM
Incubation Time:

24 h (pre-incubation prior to 6-OHDA treatment)
Result:

Did not show a significant protective effect against 6-OHDA-induced damage.

Chemical Information

CAS No. 2866266-54-6
Molecular Weight 280.36
Formula C₁₆H₂₄O₄
SMILES

CO[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tang JJ, et al. Chemical characterization and multifunctional neuroprotective effects of sesquiterpenoid-enriched Inula britannica flowers extract. Bioorganic chemistry. 2021 Nov;116:105389. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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