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Cat. No.: HY-184595

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(6-OH)-SBP-0636457

(6-OH)-SBP-0636457 is an E3 ubiquitin ligase ligand. (6-OH)-SBP-0636457 can be used to synthesize PROTAC Bcl-xL degrader-1 (HY-131188).

For research use only. We do not sell to patients.

CAS No.: 3037312-75-4
Formula: C₂₅H₃₆N₄O₅
Molecular Weight:472.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(6-OH)-SBP-0636457 Chemical Structure

CAS No.: 3037312-75-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

(6-OH)-SBP-0636457 is an E3 ubiquitin ligase ligand. (6-OH)-SBP-0636457 can be used to synthesize PROTAC Bcl-xL degrader-1 (HY-131188)^[1].

IC₅₀ & Target

IAP

All Ligands for E3 Ligase Isoforms :

In Vitro

E3 ligases catalyze the transfer of ubiquitin to target proteins and determine protein specificity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3037312-75-4
Molecular Weight 472.58
Formula C₂₅H₃₆N₄O₅
SMILES

OC1=CC2=C(C=C1)[C@H](NC([C@@H]3C(C)(C[C@@]([H])(N3C4=O)OCC[C@@H]4NC([C@@H](NC)C)=O)C)=O)CCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang X, et al.. Discovery of IAP-recruiting BCL-X PROTACs as potent degraders across multiple cancer cell lines. European journal of medicinal chemistry. 2020 Aug 01;199:112397. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
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- In Vitro
Chemical Information
Purity & Documentation
References

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(6-OH)-SBP-0636457

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(6-OH)-SBP-0636457 Related Classifications

HY-184595 Related Classifications

Bioz

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