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Cat. No.: HY-117804

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8-Br-cADPR

Name: 8-Br-cADPR
Brand: MedChemExpress
SKU: HY-117804
Availability: PreOrder

(Synonyms: 8-Bromo-Cyclic ADP-Ribose)

8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) is a membrane-permeable competitive antagonist of Cyclic ADP-ribose (cADPR) (HY-N7395) and an antagonist of TRPM2 ion channels. 8-Br-cADPR blocks cADPR-dependent RyR, SR calcium mobilization, and cADPR-mediated signaling; reduces Paclitaxel (HY-B0015)-induced axonal calcium flux, and protects against Paclitaxel-induced axonal degeneration/peripheral neuropathy. 8-Br-cADPR blocks isoproterenol-induced pulmonary artery dilation, angiotensin II-induced arterial calcium signaling/contraction, and hypoxic pulmonary vasoconstriction. 8-Br-cADPR can be used in research related to neurological diseases and cancer.

For research use only. We do not sell to patients.

CAS No.: 151898-26-9
Formula: C₁₅H₂₀BrN₅O₁₃P₂
Molecular Weight:620.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (292 KB)

8-Br-cADPR Chemical Structure

CAS No.: 151898-26-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

All Calcium Channel Isoforms :

All TRP Channel Isoforms :

In Vitro

Local Vascular RegulationNucleotide MetabolismOthers

Local Vascular Regulation

8‑Br‑cADPR (8-bromo-cADPR) blocks phase 2 HPV in isolated pulmonary artery rings, with a threshold of 3 µM and complete reversal at 100 µM; it blocks isoprenaline (HY-108353)-induced relaxation; and in acutely isolated pulmonary artery smooth muscle cells, it blocks angiotensin II-evoked calcium signaling^[4].

Nucleotide Metabolism

8-Br-cADPR does not inhibit the NADase activity of purified human SARM1 in vitro^[3].

Others

8-Br-cADPR (100 µM; administered 20 min before and during stimulation) inhibits cADPR and heat-induced OT release in isolated CD38^+/+ mouse hypothalamus^[1].
8-Br-cADPR partially reduces Paclitaxel (HY-B0015)-induced intra-axonal calcium flux in DRG sensory axons/sensory neuron axons, partially inhibits sTIR dimerization-induced axonal calcium elevation, and reduces Paclitaxel-induced axonal degeneration in a concentration-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancerApoptosisOxidative StressOthers

Anti-cancer

8-Br-cADPR (2 mg/kg; intraperitoneal injection; days 4-16; four injections in total) does not impair the antitumor efficacy of Paclitaxel in E0771 tumor-bearing C57BL/6J mice and partially rescues Paclitaxel-induced intraepidermal nerve fiber loss^[3].

Apoptosis

Oxidative Stress

8-Br-cADPR (5-20 nmol; intracerebroventricular injection; single administration; within 10 minutes) attenuates Ropivacaine (HY-B0563)-induced convulsions and reduces hippocampal cADPR, apoptosis, and oxidative stress markers in male Sprague-Dawley rats^[2].

Others

8-Br-cADPR (2 mg/kg; intraperitoneal injection; days 4 and 8; two injections total) attenuates Paclitaxel (HY-B0015)-induced mechanical allodynia and partially protects against intraepidermal nerve fiber loss^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 151898-26-9
Molecular Weight 620.20
Formula C₁₅H₂₀BrN₅O₁₃P₂
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(Br)=NC3=C2N=CN([C@H]4[C@H](O)[C@H](O)[C@@H](COP(O5)(O)=O)O4)C3=N)O[C@@H]1COP5(O)=O
Synonyms

8-Bromo-Cyclic ADP-Ribose
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (292 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhong J, et al. Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or Psychological Stress in Mice. Frontiers in neuroscience. 2016;10:304. [Content Brief]

[2]. Zou Y, et al. Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion. Chinese medical journal. 2017 Oct 05;130(19):2354-2360.

[3]. Li Y, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. The Journal of cell biology. 2022 Feb 07;221(2):e202106080. [Content Brief]

[4]. Evans AM, et al. On a Magical Mystery Tour with 8-Bromo-Cyclic ADP-Ribose: From All-or-None Block to Nanojunctions and the Cell-Wide Web. Molecules (Basel, Switzerland). 2020 Oct 16;25(20):4768.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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8-Br-cADPR

All Calcium Channel Isoforms

All TRP Channel Isoforms