Bamirastine
Bamirastine inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R) with an IC50 value of 17.3 nM.
For research use only. We do not sell to patients.
- CAS No.: 215529-47-8
- Formula: C31H37N5O3
- Molecular Weight:527.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 17.3 nM (rhH1R)[1]
In Vitro
Bamirastine (TAK-427) reduces specific binding of [3H] pyrilamine to recombinant human H1 receptors (rhH1R) is seen in a concentration- dependent manner with an IC50 value of 17.3 nM. The Ki value is calculated to be 7.35 nM. The affinity of Bamirastine is found to be as high as that of azelastine, 2 times lower than that of Epinastine, 8 times lower than that of ketotifen and 3 times higher than that of Terfenadine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 215529-47-8
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Molecular Weight 527.66
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Formula C31H37N5O3
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SMILES
O=C(O)C(C)(C)C1=CN2N=C(NCCCN3CCC(OC(C4=CC=CC=C4)C5=CC=CC=C5)CC3)C=CC2=N1
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Synonyms
TAK-427
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bamirastine Related Classifications
HY-101601 Related Classifications
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