GSK2850163 hydrochloride
Based on 9 publication(s) in Google Scholar
GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2319838-09-8
- Formula: C24H30Cl3N3O
- Molecular Weight:482.87
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-19707
4μ8CIRE1 Inhibitor -
HY-15845
STF-083010IRE1 Inhibitor -
HY-19708
KIRA6IRE1α RNase Inhibitor -
HY-139214
IXA4IRE1/XBP1s Activator -
HY-104040
MKC8866IRE1α RNase Inhibitor -
HY-19710
MKC3946IRE1 Inhibitor -
HY-136735
IRE1α kinase-IN-1IRE1α Inhibitor -
HY-17537
APY29IRE1 Inhibitor -
HY-107371
6-Bromo-2-hydroxy-3-methoxybenzaldehydeIRE1α Inhibitor -
HY-107400
B I09IRE-1 Inhibitor -
HY-12399
MKC9989HAA Inhibitor -
HY-18509
IRE1α kinase-IN-2IRE1α Knase Inhibitor
Publications Citing Use of MedChemExpress (MCE) GSK2850163 hydrochloride
More- Cell. 2026 Sep 14:S0092-8674(26)01003-2.
- Sci Signal. 2021 Jan 26;14(667):eabb3616. [Abstract]
- Mucosal Immunol. 2024 Apr;17(2):288-302. [Abstract]
- Microb Pathog. 2026 Jan 21:108313. [Abstract]
- Microbiologyopen. 2026 Feb;15(1):e70219. [Abstract]
- Cell Biochem Biophys. 2026 Sep 18.
- Vet Microbiol. 2026 May:316:110968. [Abstract]
- Vet Microbiol. 2020 May:244:108648. [Abstract]
- Res Sq. 2025 May 22.
Customer Validation & Images
-
WB
-
ELISA
-
RT-PCR
Biological Activity
Description
IC50 & Target
IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)[1]
In Vitro
GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α can be reduced in a dose-dependent manner by GSK2850163 hydrochloride. Increasing concentrations of GSK2850163 hydrochloride are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163 hydrochloride: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2319838-09-8
-
Molecular Weight 482.87
-
Formula C24H30Cl3N3O
-
SMILES
O=C(N(CCC1)C[C@]21CCN(CC3=CC=C(Cl)C(Cl)=C3)C2)NCC4=CC=C(C)C=C4.Cl
-
Synonyms
GSK163 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
-
Journal Impact Factor
-
Most Recent
-
-
Sci Signal
PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by BMPR2 mutation. [Abstract]2021 Jan 26;14(667):eabb3616. PMID: 33500333 -
Mucosal Immunol
Deficiency of immunoglobulin IgSF6 enhances antibacterial effects by promoting ER stress and the inflammatory response in intestinal macrophages. [Abstract]2024 Apr;17(2):288-302. PMID: 38387824 -
Microb Pathog
BvrR of Brucella initiates microglial inflammation through the activation of the IRE1 pathway. [Abstract]2026 Jan 21:108313. PMID: 41577152 -
Microbiologyopen
BvrR From Brucella abortus Induces Neuroinflammation Through IRE1-Mediated Activation of ATF2 and NF-κB. [Abstract]2026 Feb;15(1):e70219. PMID: 41566528
GSK2850163 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiologyopen. 2026 Feb;15(1):e70219. [Abstract]
Western blot analysis of p‐IRE1, p‐ATF2, p‐p65, IL‐6, and TNF‐α protein levels treated with GSK2850163 (8 μM).
GSK2850163 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiologyopen. 2026 Feb;15(1):e70219. [Abstract]
ELISA measurement of IL‐6 and TNF‐α in supernatants treated with GSK2850163 (8 μM).
GSK2850163 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiologyopen. 2026 Feb;15(1):e70219. [Abstract]
RT‐qPCR analysis of IL6 and TNF‐α mRNA expression treated with GSK2850163 (8 μM).
-
-
Vet Microbiol
The PERK-eIF2α branch activates the NLRP3 inflammasome through the NF-κB signaling pathway to suppress NDV replication. [Abstract]2026 May:316:110968. PMID: 41793984 -
Vet Microbiol
A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway. [Abstract]2020 May:244:108648. PMID: 32402333 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK2850163 hydrochloride Related Classifications
HY-U00459B Related Classifications
Powered by Bioz