MHP 133
MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
For research use only. We do not sell to patients.
- CAS No.: 147340-43-0
- Formula: C17H20ClN5O3
- Molecular Weight:377.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-N0342
ScopoletinCholinesterase (ChE) Inhibitor -
HY-N0342R
Scopoletin (Standard)Cholinesterase (ChE) Inhibitor -
HY-A0009
Galanthamine hydrobromideAChE Inhibitor -
HY-75247
CoumaranAChE Inhibitor -
HY-103374
PhenserineAChE Inhibitor -
HY-17388
(±)-Huperzine ADrug Isomer -
HY-75247R
Coumaran (Standard)AChE Inhibitor -
HY-A0009R
Galanthamine hydrobromide (Standard)AChE Inhibitor
All 5-HT Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
mAChR1 |
mAChR2 |
5-HT4 Receptor |
AChE 69 μM (Ki) |
In Vitro
MHP-133 is be active (>50% displacement or activity) against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. MHP-133 exhibits this nicotinic-like activity in the cell line. Although the ED50 for inducing TrkA expression is only about 1 μM, it does predicts the cytoprotective action of MHP-133 in differentiated PC-12 cells deprived of growth factor for 24 h. MHP-133 (10-100 μM) significantly increases the levels of sAPP from cultured astrocytes by 40-60%. MHP-133 produces a bi-phasic effect on slice survival, particularly in the dentate gyrus and the CA1 regions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 147340-43-0
-
Molecular Weight 377.83
-
Formula C17H20ClN5O3
-
SMILES
O=C(N/N=C/C1=C(OC(N(C)C)=O)C=CC=[N+]1C)NC2=CC=CC=C2.[Cl-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MHP 133 Related Classifications
HY-101653 Related Classifications
Powered by Bioz