Animal Venoms

Convulxin is a toxin found in a tropical rattlesnake. Convulxin stimulates platelet aggregation, and clusters GPVI to trigger Src family kinase activation, Fc receptor γ chain phosphorylation, and p72SYK signaling. Convulxin interacts with Dectin-2 to induce IL-10 production, activates monocytes to generate ROS and NLRP3 inflammasome-mediated IL-1β secretion, and induces mitochondrial ROS. Convulxin causes transient arterial blood pressure changes in dogs. Convulxin can be used for research related to coagulation.

Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC₅₀ = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer.

Dendrotoxin-I (DTX-I) is a potent K⁺ channels blocker with IC₅₀s of 0.13-50 nM for voltage-gated potassium channel subunits K_V1.1, K_V1.2 and K_V1.6, respectively. Dendrotoxin-I, a neurotoxin, has the potential for cancer research.

Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases.

Trigochinin B is a natural product.

Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel.