Myricaceae Extract

Myricanol is a diarylheptanoid and a Nampt activator. Myricanol exerts anti-inflammatory effects and alleviates glucocorticoid-induced muscle atrophy by increasing Sirtuin 1 (SIRT1) and PRDX5 activities while regulating inflammatory factors. Myricanol exhibits growth inhibition and induces apoptosis in human lung adenocarcinoma A549 cells. Myricanol promotes autophagy-mediated clearance of microtubule-associated protein tau to exert neuroprotective effects. Myricanol protects cardiovascular function by inhibiting PDGFRβ and NF-κB signaling pathways. Myricanol activates mitochondrial transcription factor A (TFAM) expression to exert anti-renal fibrosis effects. Myricanol improves insulin resistance through AMPK activation.

Myricadenin A is an iNOS inhibitor, capable of effectively inhibiting the production of NO (EC₅₀ = 18.1 μM). Myricadenin A has moderate ABTS free radical scavenging activity (SC₅₀ = 175.4 μM) and relatively weak anti-tuberculosis activity (MIC = 80.0 μg/mL). Myricadenin A can be used in inflammation-related research.

Porsone (Porson) is a cyclic diarylheptanoid, that can be isolated from the roots of Myrica nana.

5-O-beta-D-Glucopyranosylmyricanol is a diarylheptane compound isolated from Myrica esculenta that has a weak inhibitory effect on angiotensin-converting enzyme (ACE).

12-Hydroxymyricanone is a nature product that could be isolated from the roots of Myrica nana. 12-Hydroxymyricanone inhibits the release of nitric oxide with an IC₅₀ value of 30.19 μM.

Myrigalone A (MyA) is a plant ethylene biosynthesis inhibitor and natural herbicide. Myrigalone A possesses antioxidant, antifungal, and antimicrobial activities. Myrigalone A interferes with auxin homeostasis during seed germination. Myrigalone A delays seed germination, inhibits the formation of roots, hypocotyls, and root hairs, and causes developmental delay in specific organisms. Myrigalone A triggers the induction of detoxification programs, alters the metabolism of gibberellins, cis-(+)-12-oxophytodienoic acid, and jasmonic acid, disrupts the antioxidant system and oxidative signaling, and impairs the function of aquaporins and water uptake in imbibed seeds. Myrigalone A can be used in studies related to herbicides and plant growth regulators.

3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid is a Triterpenoids product that can be isolated from the herbs of Myrica nana.

Myricanol triacetate is a Phenols product that can be isolated from the root barks of Myrica cerifera L..

Alnusonol is a natural product.

(+)-S-Myricanol glucoside is a Phenols product that can be isolated from the root barks of Myrica cerifera L..