CaMK Modulator
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BRD0418
0 ImagesBRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) .
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Ph-HTBA
0 ImagesCat. No.: HY-151797CAS No.: 2368927-41-5Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.
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CaMKI(299-320)
0 ImagesCat. No.: HY-P10316CAS No.: 205598-38-5Synonyms: Calmodulin-Dependent Protein Kinase I (299-320) Binding DomainCaMKI (299-320) refers to a peptide consisting of residues 299-320 of Calcium/calmodulin-dependent protein kinase I (CaMKI). CaMKI (299-320), as a protein kinase, has a high affinity interaction with Ca2+-CAM (Kd≤1 nM≤1 nM), which can phosphorylate specific substrate proteins, thereby regulating their activity. CaMKI (299-320) contains the CAM-binding domain and the self-inhibition domain, and CaMKI (299-320) can be used to study cell physiological processes, including cell proliferation, differentiation, and apoptosis.
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MRS2957
0 ImagesCat. No.: HY-108664CAS No.: 1228271-30-4MRS2957 is a selective P2Y6 receptor agonist. MRS2957 activates Gq-coupled purinergic receptors, increasing phospholipase C, inositol trisphosphate, and intracellular calcium, and indirectly activates AMPK via CaMKKβ, thereby promoting P2Y6-dependent glucose uptake and GLUT4 translocation in skeletal muscle cells and adipocytes. MRS2957 can be used for research on type 2 diabetes.
