HDAC7 Degrader
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YL633
0 ImagesCat. No.: HY-189839CAS No.: 3100239-28-6YL633 is a selective CRBN-recruiting HDAC8 PROTAC degrader with DC50 = 3.3 nM. YL633 binds to the CRBN E3 ubiquitin ligase and mediates HDAC8 degradation. YL633 inhibits HDAC3 enzymatic activity with IC50 of 342.9 nM, and induces degradation of HDAC6 and HDAC7. YL633 inhibits DLBCL cell proliferation. YL633 can be used in research related to diffuse large B-cell lymphoma.
