IL-8 Modulator
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EM982
0 ImagesCat. No.: HY-189761EM982 is an Erythromycin (HY-B0220)-derived IKKβ inhibitor that blocks IKKβ/IκBα phosphorylation and Toll-like receptor ligand-induced NF-κB activation. EM982 downregulates TNF‑α, IL‑6, and IL‑8, while upregulating IL‑10. EM982 can be used in immunomodulation-related research.
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APH003
0 ImagesCat. No.: HY-184915CAS No.: 3065495-08-8APH003 is an orally active IRAK4 PROTAC degrader with a DC50 of 0.74 nM in human peripheral blood mononuclear cells (hPBMCs). APH003 recruits IRAK4 to CRBN to form a ternary complex, mediates the ubiquitination and degradation of IRAK4 via the ubiquitin-proteasome pathway, and inhibits the kinase activity of IRAK4. APH003 inhibits LPS- or IL-1β/LPS-induced phosphorylation of ERK, JNK and NF-κB. APH003 inhibits the secretion of TNF-α, IL-6, IL-8 and IL-13 by stimulated hPBMCs. APH003 exhibits anti-inflammatory activity in rat TNBS-induced intestinal inflammation models and mouse IL-33-induced skin inflammation models. APH003 can be used in research related to inflammatory bowel disease and skin inflammation.
