PTEN Modulator
-
EGFR-IN-192
0 ImagesCat. No.: HY-181097EGFR-IN-192 is an anticancer agent. EGFR-IN-192 inhibits EGFR (IC50: 0.12 μM), downregulates the HIF-VEGF and PI3K/AKT/mTOR pathways, upregulates the tumor suppressor gene PTEN, and induces cell cycle arrest and apoptosis in tumor cells. EGFR-IN-192 exhibits antitumor activity and can be used in tumor research.
-
DFX117
0 ImagesCat. No.: HY-164384CAS No.: 2125500-60-7DFX117 is an orally active PI3Kα/c-Met inhibitor. DFX117 blocks PI3K/Akt and Met downstream signaling through selective inhibition of PI3Kα (IC50 = 0.5 nM) and c-Met tyrosine kinase activity (IC50 = 17.1 nM), and induces G0/G1 phase arrest, caspase-dependent intrinsic apoptosis (apoptosis), and PTEN upregulation in non-small cell lung cancer cells, thereby inhibiting tumor growth. DFX117 can be used for research on non-small cell lung cancer.
