Actin Activator
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3-(4-Pyridyl)indole
0 ImagesSynonyms: Rockout; 3-(4-Pyridinyl)-1H-indole; Rho Kinase Inhibitor III, Rockout3-(4-Pyridyl)indole (Rockout; 3-(4-Pyridinyl)-1H-indole; Rho Kinase Inhibitor III, Rockout) is a Rho-kinase inhibitor (IC50 = 25 μM). 3-(4-Pyridyl)indole inhibits cell migration, membrane blebbing, and stress fiber and focal adhesion formation, and induces actin stress fiber disassembly. 3-(4-Pyridyl)indole promotes cell spreading and alters cell morphology and dynamics. 3-(4-Pyridyl)indole inhibits PRK2. 3-(4-Pyridyl)indole is used in wound healing research.
