FOXA3
FOXA3 belongs to FOXA protein family. FOXA3 is a positive regulator of adipocyte differentiation. FOXA3 promotes adipocyte differentiation by inducing PPARγ expression. This process is accomplished by the synergistic transcription of FOXA3 with C/EBPΒ and C/EBPδ. HFD selectively induced FOXA3 in epithelial fat, while removal of FOXA3 in mice prevented weight gain and the development of visceral obesity, as well as adipocytes obtained from visceral fat expressing lower levels of PPARγ and differentiation marker. FOXA3 is not essential for controlling islet or intestinal glucagon gene expression. Hepatic FOXA3 is a positive regulator of plasma ApoA-I, HDL-C levels and reversal of cholesterol transport[1].
