FOXP1
FOXP1 belongs to the forkhead box protein P (FOXP) family. FOXP1 is highly expressed in the nervous system and regulate molecular pathways required for proper brain development and function. FOXP1 regulates development of B cells. FOXP1 has protein-protein interaction with NFAT1 to enhance breast cancer cell motility. Furthermore, overexpression of FOXP1 inhibits proliferation and invasion in U251 glioma cells, while knockdown of FOXP1 promotes the development of lung carcinoma. FOXP1 is also known to interact with FOXP3 through NFAT-IL-2 promoter DNA complexes[1][2].
References:
- [1]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
- [2]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
