FOXP2
FOXP2 belongs to the forkhead box protein P (FOXP) family. FOXP2 is highly expressed in the nervous system and regulate molecular pathways required for proper brain development and function. FOXP2 is essential in growth arrest of 143 osteosarcoma cells via p21 activation. FOXP2 suppresses the transcriptional activity of target genes through the Zinc finger domain and also binds to domain for C-Terminal Binding Protein-1 (CtBP1) for suppressing E-cadherin and promoting invasion. The downregulation of FOXP2 enhances tumor initiation in breast cancers as a putative tumor/metastasis suppressor. Also, FOXP2 is downregulated in hepatocellular carcinoma (HCC) tumor tissues. Furthermore, FOXP2 is regarded as a SUMO target protein at cellular level, since FOXP2 is covalently modulated by both SUMO1 and SUMO3. SUMOylation of FOXP2 is significantly disturbed by a specific SUMO Specific Protease 2 (SENP2), since SUMOylation modulates transcriptional activity of FOXP2 in targeting downstream target genes (DISC1, SRPX2, and MiR200c) by reporter gene assay[1][2].
References:
- [1]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
- [2]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
