Glutathione Reductase (GR) Substrate
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GSeSeG
0 ImagesGSeSeG (Glutaselenone diselenide) is the oxidized diselenide form of selenoglutathione (GSeH), a selenium analog of glutathione in which selenocysteine replaces cysteine. GSeSeG serves as a substrate for Glutathione Reductase (GR) with a Km of 54 μM. GSeSeG is reduced by the GR/NADPH system to generate GSeH. GSeSeG also promotes the oxidative folding of disulfide-containing proteins and the rearrangement of incorrect disulfide bonds. GSeSeG is used in studies of redox regulation, oxidative/glycation stress, and protein folding.
