β-Amyloid (22-35)
β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution).
For research use only. We do not sell to patients.
- CAS No.: 144189-71-9
- Formula: C59H102N16O21S
- Molecular Weight:1403.62
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-P1388
β-Amyloid (1-42), (rat/mouse)β-Amyloid (1-42) Peptide -
HY-P1362
β-Amyloid (42-1), humanInactive Form of Aβ(1-42) -
HY-P1363A
β-Amyloid (1-42), humanAmyloid β Peptide -
HY-P1363B
β-Amyloid (1-42), human, HFIP-treatedβ-Amyloid (1-42) Peptide -
HY-P0128
β-Amyloid (25-35)Amyloid β Peptide -
HY-P1466
β-Amyloid (1-16)β-Amyloid -
HY-P1046
β-Amyloid (1-15)Peptide Fragment -
HY-P1517
β-Amyloid (31-35)β-Amyloid Peptide Fragment -
HY-P0128A
β-Amyloid (25-35), HFIP-treatedAmyloid β Peptide -
HY-N0615
Notoginsenoside R1Apoptosis Inhibitor -
HY-P1468
β-Amyloid (1-28)Amyloid-β Peptide -
HY-P1522
β-Amyloid (29-40)Amyloid-β Peptide Fragment
Biological Activity
Description
IC50 & Target
Amyloid-β[1]
In Vitro
β-Amyloid 22-35 shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 144189-71-9
-
Molecular Weight 1403.62
-
Formula C59H102N16O21S
-
Synonyms
Amyloid β-Protein (22-35)
-
Sequence
Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met
-
Sequence Shortening
EDVGSNKGAIIGLM
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Takadera T, et al. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett. 1993 Oct 14;161(1):41-4. [Content Brief]
[2]. Zhou WW, et al. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med. 2014;74:50-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Amyloid (22-35) Related Classifications
HY-P1474 Related Classifications
Powered by Bioz