Ac-rC Phosphoramidite-13C9
Based on 1 Customer Validation
Ac-rC Phosphoramidite-13C9 is 13C-labeled Ac-rC Phosphoramidite (HY-W042357). Ac-rC Phosphoramidite is used for the oligoribonucleotide phosphorodithioate modification (PS2-RNA).
For research use only. We do not sell to patients.
- Purity : 95%
- Formula: C3813C9H64N5O9PSi
- Molecular Weight:911.03
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Appearance Solid
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Molecular Weight 911.03
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Formula C3813C9H64N5O9PSi
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SMILES
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)O[13CH2][13C@@H]4[13C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[13C@@H](O[Si](C)(C)C(C)(C)C)[13C@H](N5[13C](N=[13C](NC(C)=O)[13CH]=[13CH]5)=O)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (109.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Wipapat Kladwang, et al. Anomalous Reverse Transcription through Chemical Modifications in Polyadenosine Stretches. Biochemistry. 2020 Jun 16;59(23):2154-2170. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0977 mL | 5.4883 mL | 10.9766 mL | 27.4415 mL |
| 5 mM | 0.2195 mL | 1.0977 mL | 2.1953 mL | 5.4883 mL | |
| 10 mM | 0.1098 mL | 0.5488 mL | 1.0977 mL | 2.7441 mL | |
| 15 mM | 0.0732 mL | 0.3659 mL | 0.7318 mL | 1.8294 mL | |
| 20 mM | 0.0549 mL | 0.2744 mL | 0.5488 mL | 1.3721 mL | |
| 25 mM | 0.0439 mL | 0.2195 mL | 0.4391 mL | 1.0977 mL | |
| 30 mM | 0.0366 mL | 0.1829 mL | 0.3659 mL | 0.9147 mL | |
| 40 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6860 mL | |
| 50 mM | 0.0220 mL | 0.1098 mL | 0.2195 mL | 0.5488 mL | |
| 60 mM | 0.0183 mL | 0.0915 mL | 0.1829 mL | 0.4574 mL | |
| 80 mM | 0.0137 mL | 0.0686 mL | 0.1372 mL | 0.3430 mL | |
| 100 mM | 0.0110 mL | 0.0549 mL | 0.1098 mL | 0.2744 mL |
Ac-rC Phosphoramidite-13C9 Related Classifications
HY-W042357S4 Related Classifications
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