Acetylcholine-d16 bromide
Based on 1 Customer Validation
Acetylcholine-d16 (ACh-d16) bromide is the deuterated-labeled Acetylcholine bromide (HY-B0282A). Acetylcholine (ACh) bromide, a neurotransmitter, is a potent cholinergic agonist. Acetylcholine bromide is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs). Acetylcholine bromide inhibits p53 mutant peptide aggregation in vitro.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 347841-43-4
- Formula: C7D16BrNO2
- Molecular Weight:242.21
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 347841-43-4
-
Unlabeled CAS 66-23-9
-
Appearance Solid
-
Molecular Weight 242.21
-
Formula C7D16BrNO2
-
Color White to off-white
-
SMILES
[2H]C([2H])([2H])C(OC([2H])([2H])C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.[Br-]
-
Synonyms
ACh-d16 bromide
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 250 mg/mL (1032.16 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (295 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[2]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9. [Content Brief]
[3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41. [Content Brief]
[4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2. [Content Brief]
[5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.1286 mL | 20.6432 mL | 41.2865 mL | 103.2162 mL |
| 5 mM | 0.8257 mL | 4.1286 mL | 8.2573 mL | 20.6432 mL | |
| 10 mM | 0.4129 mL | 2.0643 mL | 4.1286 mL | 10.3216 mL | |
| 15 mM | 0.2752 mL | 1.3762 mL | 2.7524 mL | 6.8811 mL | |
| 20 mM | 0.2064 mL | 1.0322 mL | 2.0643 mL | 5.1608 mL | |
| 25 mM | 0.1651 mL | 0.8257 mL | 1.6515 mL | 4.1286 mL | |
| 30 mM | 0.1376 mL | 0.6881 mL | 1.3762 mL | 3.4405 mL | |
| 40 mM | 0.1032 mL | 0.5161 mL | 1.0322 mL | 2.5804 mL | |
| 50 mM | 0.0826 mL | 0.4129 mL | 0.8257 mL | 2.0643 mL | |
| 60 mM | 0.0688 mL | 0.3441 mL | 0.6881 mL | 1.7203 mL | |
| 80 mM | 0.0516 mL | 0.2580 mL | 0.5161 mL | 1.2902 mL | |
| 100 mM | 0.0413 mL | 0.2064 mL | 0.4129 mL | 1.0322 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetylcholine-d16 bromide Related Classifications
HY-B0282AS3 Related Classifications
Powered by Bioz