AChE/BChE-IN-38
AChE/BChE-IN-38 is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 = 1.22 μM and 0.40 μM; Ki = 0.94 μM and 0.60 μM). AChE/BChE-IN-38 decreases BACE1 and HTR6 mRNA expression in neuroblastoma cells. AChE/BChE-IN-38 improves cognitive and behavioral parameters in a Scopolamine-induced Alzheimer's disease zebrafish model. AChE/BChE-IN-38 is useful for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C29H25BrClN3O2
- Molecular Weight:562.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
AChE 1.22 μM (IC50) |
AChE 0.94 μM (Ki) |
BChE 0.4 μM (IC50) |
BChE 0.6 μM (Ki) |
BACE1 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y
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Concentration:25 µM
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Incubation Time:72 h
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Result:Significantly reduced the mRNA levels of BACE1 by approximately 50%.
Decreased the mRNA level of HTR6 by around 29%.
No significant effects on the mRNA levels of GSK-3α and GSK-3β were observed.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult zebrafish (Danio rerio) (0.2-0.25 g)[1]
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Dosage:0.3, 0.15 mg/fish+1mg Scopolamine 24 h
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Administration:single dose
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Result:Increased swimming distance, increased the frequency of crossing the midline, raised swimming speed, and extend time spent in the upper zone.
Chemical Information
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Molecular Weight 562.88
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Formula C29H25BrClN3O2
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SMILES
ClC1=CC=CC=C1C[N+]2=CC(CNC(C(C=C3)=CC=C3CN4CC5=CC=CC=C5C4=O)=O)=CC=C2.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-38 Related Classifications
HY-189414 Related Classifications
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